Results of bone marrow examination in 275 patients with histological features that suggest an indolent type of cutaneous B-cell lymphoma

British Journal of Haematology
Nancy J SenffRein Willemze

Abstract

Whether or not bone marrow biopsies should be performed routinely in patients with skin lesions that show histological features consistent with an indolent B-cell lymphoma [marginal zone lymphoma (MZL) or follicle centre lymphoma (FCL)] has been debated. As no studies have addressed this question for this group of lymphomas, we evaluated the results of bone marrow biopsy examination in 275 patients with histological features consistent with MZL (n = 82) or FCL (n = 193) first presenting in the skin. In the MZL group, two of 82 patients (2%) showed bone marrow involvement, which was the only extracutaneous localization in one of these patients. In the FCL group, 22 of 193 patients (11%) had bone marrow involvement and was the only extracutaneous localization in nine of them. FCL patients with skin lesions and a positive bone marrow had a significantly worse prognosis when compared with patients with only skin lesions (5-year disease-specific survival 63% vs. 95%; P = 0.001). These results indicate that bone marrow investigation is essential for staging patients with a FCL first presenting in the skin. Bone marrow examination appears to have limited value in patients with MZL presenting in the skin.

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P L ZinzaniS Tura
Nov 29, 2002·Blood·Emanuele ZuccaUNKNOWN International Extranodal Lymphoma Study Group
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Jun 14, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Markus RadererAndreas Chott
Nov 18, 2006·The Oncologist·Seth M CohenMichael L Grossbard
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
Jun 23, 2007·Critical Reviews in Oncology/hematology·Andrés J M Ferreri, Emanuele Zucca

❮ Previous
Next ❯

Citations

Jul 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R WillemzeUNKNOWN ESMO Guidelines Working Group
Nov 26, 2010·The American Journal of Surgical Pathology·James T EdingerSteven H Swerdlow
Aug 21, 2013·Actas dermo-sifiliográficas·C Muniesa, B Hernández-Machín
Oct 13, 2009·Critical Reviews in Oncology/hematology·Stéphane DalleCatherine Thieblemont
Jan 9, 2010·Histopathology·Werner Kempf, Christian A Sander
Aug 12, 2016·Indian Journal of Dermatology·Yann Vincent Charli-JosephLaura Beth Pincus
Dec 20, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jan P Nicolay, Marion Wobser
Dec 20, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jan P Nicolay, Marion Wobser
Jan 28, 2014·Current Opinion in Oncology·Maarten H Vermeer, Rein Willemze
Feb 20, 2015·American Journal of Clinical Pathology·Anne Pham-LedardMarie Beylot-Barry
Jun 8, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R WillemzeUNKNOWN ESMO Guidelines Committee
Nov 9, 2018·Archives of Pathology & Laboratory Medicine·Stephanie L SkalaAlexandra C Hristov
Dec 4, 2019·Journal of Pediatric Gastroenterology and Nutrition·Wael N SayejJeffrey S Hyams
Aug 21, 2020·American Journal of Hematology·Alexandra C HristovRyan A Wilcox
Jun 20, 2012·Cancer Control : Journal of the Moffitt Cancer Center·Lubomir SokolL Frank Glass
Aug 19, 2020·American Journal of Clinical Pathology·Sarah E Gibson, Steven H Swerdlow
Aug 3, 2017·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Wobser
Jan 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Wael N SayejJeffrey S Hyams
Jul 14, 2020·Frontiers in Oncology·Giulia Tadiotto CicognaMauro Alaibac
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R WillemzeUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.