PMID: 7518815Jul 1, 1994Paper

Results of combined external irradiation and chemotherapy of bleomycin or peplomycin for squamous cell carcinomas of the lower gingiva

International Journal of Radiation Oncology, Biology, Physics
H FuchihataN Masaki

Abstract

In Japan, the role of radiotherapy for gingival carcinomas has not been considered as a radical treatment, but only a pre and/or postoperative treatment. This study was aimed to discuss a possibility of radiotherapy for a radical treatment. In this study, radiotherapy was given as an initial treatment for squamous cell carcinomas of the lower gingiva in simultaneous combination with chemotherapy of bleomycin or peplomycin (Tokyo, Japan). When complete regression of the tumor was obtained, subsequent surgery was postponed with or without a booster of radiotherapy of about 30 Gy until a recurrent lesion was confirmed. Sixty-seven percent of 100 patients with T1 or T2 had complete regression, while only 22 (35.5%) of 62 patients with T3 or T4 had complete regression. The 5-year local control rate by T classification, including the results of secondary treatments (surgery and/or radiotherapy and/or chemotherapy) for recurrent lesions, was 91% for T1, 89% for T2, 76% for T3 and 61% for T4. The 5-year local control rate according to treatment methods was 95% in the group without surgery and 86% in the group with surgery for T1 and T2 patients. The rates were 54% and 71%, respectively for T3 and T4 patients. The cause specific 5-year ...Continue Reading

References

Oct 1, 1973·Acta Radiologica: Therapy, Physics, Biology·J V Fayos
Mar 1, 1969·Cancer·B Cady, D Catlin

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Citations

Dec 14, 2011·Japanese Journal of Radiology·Masashi ChataniHideo Yoshioka
Jan 1, 1996·The Veterinary Clinics of North America. Small Animal Practice·R L Burk
Jun 29, 2010·Veterinary and Comparative Oncology·J M KellyA K Schaefer

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