Results of intensive long-term treatment of familial hypercholesterolemia

The American Journal of Cardiology
K RetterstølL Ose

Abstract

Fifty-seven patients with familial hypercholesterolemia (FH) with mean age of 48 years (range 30 to 69), participated in a follow-up examination 5.5 years after the completion of a 1-year trial with lovastatin, cholestyramine, probucol, or omega-3 fatty acids. The goals were to record quality of life, compliance to treatment, adverse effects, and clinical outcome. The quality of life was similar to that in a Norwegian reference population. The factors causing most distress to patients were keeping a diet low in saturated fats, taking medication, and fear of death. The medication was mostly prescribed in maximum dosages. At follow-up, the reduction in total cholesterol was 36% (p < 0.05), low-density lipoprotein (LDL) cholesterol 38% (p < 0.05), triglycerides 20% (p < 0.05) compared with being on diet therapy only. High-density lipoprotein (HDL) cholesterol increased 8% (p < 0.05). Intake of saturated and monounsaturated fat increased 1.5% and 1.7% (p < 0.05), respectively; polyunsaturated fat was unchanged. Three patients experienced myocardial infarction, of whom 2 died and 1 developed angina pectoris. Before the start of lovastatin treatment, 27 coronary events occurred per 1,000 patient-years in this group compared with 12 e...Continue Reading

References

Dec 19, 1990·JAMA : the Journal of the American Medical Association·J P KaneR J Havel
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K FolkersH Tamagawa
Aug 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·F A HuppertB J Elliott
Apr 4, 1986·Science·M S Brown, J L Goldstein
Jan 1, 1994·European Journal of Clinical Pharmacology·R LaaksonenJ J Himberg

❮ Previous
Next ❯

Citations

Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S RaoK Keyomarsi
Apr 11, 2008·International Journal of Technology Assessment in Health Care·Laura HyttinenTimo E Strandberg
Apr 16, 2002·Journal of Internal Medicine·G HollmanA G Olsson
Sep 18, 2007·The Journal of Nutritional Biochemistry·Mee Young HongDavid Heber
Mar 25, 2005·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·J A JacksonP Dalgarno
Nov 5, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Vassilis H AletrasJohn N Yfantopoulos
Oct 30, 2015·Circulation·Samuel S GiddingUNKNOWN American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascula
Oct 21, 2004·The Cochrane Database of Systematic Reviews·L HooperS B J Ebrahim
Dec 12, 2002·The Journal of Biological Chemistry·Chinweike Ukomadu, Anindya Dutta
Jul 30, 2002·The American Journal of Clinical Nutrition·Agot L AmundsenFady Y Ntanios

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.