PMID: 2112976Jul 1, 1990Paper

Results of neoadjuvant chemotherapy and radiation therapy in the breast-conserving treatment of 250 patients with all stages of infiltrative breast cancer

Cancer
C JacquillatC Soubrane

Abstract

Two hundred fifty evaluable patients with breast cancer entered a protocol combining neoadjuvant and consolidation therapy by vinblastine (V), thiotepa (T), methotrexate (M), and 5-fluorouracil (F) (VTMF), with or without Adriamycin (A) (doxorubicin; Adria Laboratories, Columbus, OH), and radiation therapy as exclusive locoregional treatment. Tamoxifen was given to 195 patients (130 postmenopausal and 65 premenopausal) and was omitted in 55 patients (31 postmenopausal and 24 premenopausal). There were 19 Stage I, 86 Stage IIA, 51 Stage IIB, 36 Stage IIIA, and 58 Stage IIIB patients. Primary chemotherapy induced tumor volume regression of more than 75% in 41% of the patients and complete clinical regression in 30% of the patients. The 5-year disease-free survival (DFS) rates were 100% for Stage I, 82% for Stage IIA, 61% for Stage IIB, 46% for Stage IIIA, and 52% for Stage IIIB patients. Among the 72 primary relapses there were 39 distant metastases. The actuarial rate of locoregional recurrence was 13% for T2, 18% for T3, and 19% for T4. At 5 years the rate of breast preservation was 94%. Cosmetic results were excellent or good for most patients. The 5-year overall survival (OS) rates were 95% for Stage I, 94% for Stage IIA, 80%...Continue Reading

References

Sep 1, 1979·Cancer·R G CooperO Glidewell
Feb 1, 1979·Maturitas·O Lindquist, C Bengtsson
Jan 16, 1975·The New England Journal of Medicine·B FisherE R Fisher
Feb 19, 1976·The New England Journal of Medicine·G BonadonnaU Veronesi
Feb 23, 1989·The New England Journal of Medicine·UNKNOWN Ludwig Breast Cancer Study Group
Jan 1, 1989·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·W M Hryniuk
Feb 23, 1989·The New England Journal of Medicine·E G MansourG Falkson
Dec 29, 1988·The New England Journal of Medicine·UNKNOWN Early Breast Cancer Trialists' Collaborative Group
Jul 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FowbleD C Tormey
Dec 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J RouësséF May-Levin
Jan 1, 1985·Breast Cancer Research and Treatment·G BonadonnaU Veronesi
Oct 1, 1985·International Journal of Radiation Oncology, Biology, Physics·C Schaake-KoningE Engelsman
Jun 1, 1985·The Journal of Antimicrobial Chemotherapy·D LoebenbergG H Miller
May 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D StefanikA Dritschilo
Nov 1, 1983·International Journal of Radiation Oncology, Biology, Physics·B F DanoffT F Pajak
Nov 1, 1984·European Journal of Cancer & Clinical Oncology·H M KantarjianR G Martin
Jan 1, 1981·Cancer·A B MillerA Winkler

❮ Previous
Next ❯

Citations

Jul 28, 2001·International Journal of Cancer. Journal International Du Cancer·E CalitchiJ P Le Bourgeois
Jan 1, 1994·World Journal of Surgery·P I Borgen
Jan 1, 1996·Breast Cancer Research and Treatment·P L DavisH Tobon
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·H J SennB Thürlimann
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M HiraokaM Kokubo
Jan 16, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·S D Heys
Sep 25, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Georgios Koukourakis
Mar 15, 1996·International Journal of Radiation Oncology, Biology, Physics·L J Pierce
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C K MannesseT A Splinter
Apr 20, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C HennequinC Maylin
Jun 26, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D LerougeJ Blondon
Mar 27, 1998·American Journal of Surgery·A EltahirO Eremin
Mar 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E TouboulM Schlienger
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Eugene HuangThomas A Buchholz
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·J ClarkM Graham
Jun 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E BussièresM Durand
Oct 2, 1998·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I E Smith, M al-Moundhri
Nov 1, 2001·Journal de radiologie·J Verdenet, F Langevin
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P CholletJ P Ferrière
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M ColleoniA Orecchia
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A C BraudP Pouillart
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L G WalkerO Eremin
Dec 17, 2002·Critical Reviews in Oncology/hematology·Catherine Shannon, Ian Smith
Mar 7, 2000·Journal of the American College of Surgeons·H M KuererS E Singletary
Mar 22, 2002·The Lancet Oncology·I E Smith, L Lipton
Nov 1, 2002·Breast Cancer Research and Treatment·Hervé CuréPhilippe Chollet
Aug 6, 1992·The New England Journal of Medicine·J R HarrisW Willett
Aug 1, 1994·Annals of Surgery·T J Eberlein
Jul 26, 2005·Annals of Surgery·Helena M VerkooijenChristine Bouchardy
Mar 3, 2006·The Breast Journal·Sushil BeriwalJorge A Garcia-Young
Aug 23, 2003·World Journal of Surgical Oncology·Steven D Heys, Shailesh Chaturvedi
Feb 14, 1998·European Journal of Cancer Care·A Makris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
E BélembaogoY J Bignon
International Journal of Radiation Oncology, Biology, Physics
L J PierceK H Cowan
© 2021 Meta ULC. All rights reserved