Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery

Journal of Vascular Surgery
Michael S ContePREVENT III Investigators

Abstract

The PREVENT III study was a prospective, randomized, double-blinded, multicenter phase III trial of a novel molecular therapy (edifoligide; E2F decoy) for the prevention of vein graft failure in patients undergoing infrainguinal revascularization for critical limb ischemia (CLI). From November 2001 through October 2003, 1404 patients with CLI were randomized to a single intraoperative ex vivo vein graft treatment with edifoligide or placebo. After surgery, patients underwent graft surveillance by duplex ultrasonography and were followed up for index graft and limb end points to 1 year. A blinded Clinical Events Classification committee reviewed all index graft end points. The primary study end point was the time to nontechnical index graft reintervention or major amputation due to index graft failure. Secondary end points included all-cause graft failure, clinically significant graft stenosis (>70% by angiography or severe stenosis by ultrasonography), amputation/reintervention-free survival, and nontechnical primary graft patency. Event rates were based on Kaplan-Meier estimates. Time-to-event end points were compared by using the log-rank test. Demographics, comorbidities, and procedural details reflected a population with CL...Continue Reading

References

Feb 1, 1990·Journal of Vascular Surgery·L M TaylorJ M Porter
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·R MorishitaV J Dzau
Oct 6, 1997·Journal of Vascular Surgery·R B RutherfordD N Jones
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·M J MannV J Dzau
Nov 8, 2002·Journal of Vascular Surgery·Michael S ConteRichard C Mulligan
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Michael J Mann, Michael S Conte

❮ Previous
Next ❯

Citations

Jul 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rowan FlynnDavid A Dichek
Mar 29, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Richard J PowellRonnda L Bartel
Oct 3, 2007·Gene Therapy·B L AlexanderS Ylä-Herttuala
Feb 23, 2011·The Journal of Experimental Medicine·Akihito MutoAlan Dardik
Jan 8, 2009·Oligonucleotides·Tobias WalkerGerhard Ziemer
Aug 6, 2009·Oligonucleotides·Kristina W Thiel, Paloma H Giangrande
Jul 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Karen J HoMichael S Conte
Jul 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Zhihua JiangScott A Berceli
Jan 6, 2012·Journal of Translational Medicine·Jiangbin SunXiufen Zheng
May 17, 2011·Journal of Cardiothoracic Surgery·Junjie ZouShui Wang
Mar 28, 2013·PloS One·Minki HwangRoger Tran-Son-Tay
Dec 6, 2012·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Peadar S WatersSherif Sultan
Jul 1, 2006·Future Cardiology·Xinjiang Cai, Neil J Freedman
Feb 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuya MiyaharaMichael S Conte
Apr 23, 2013·Current Cardiology Reports·Matthew C Bunte, Mehdi H Shishehbor
Feb 11, 2016·Journal of Vascular Surgery·Ann D SmithLouis L Nguyen
Feb 26, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J MalmstedtJ Swedenborg
Oct 8, 2013·Journal of Vascular Surgery·Justin R WallaceMichel S Makaroun
Nov 2, 2013·Journal of Vascular Surgery·Virendra I PatelRichard P Cambria
Dec 18, 2013·Annals of Vascular Surgery·Neal R BarshesMichael Belkin
Nov 26, 2013·Surgery·Gauthami SomaK Craig Kent
Sep 10, 2013·Annals of Vascular Surgery·Andrew J MeltzerDarren B Schneider
Jul 24, 2013·Journal of Vascular Surgery·Peng YuC Keith Ozaki
Jul 24, 2013·Journal of Vascular Surgery·Adriana HarbuzariuBryan W Tillman
Dec 3, 2014·Journal of Vascular Surgery·Daniel J WongAlan Dardik
Jan 1, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Kevin W SoutherlandChristopher D Kontos
Jul 17, 2012·Pharmacology & Therapeutics·Keith E RobertsonAndrew H Baker
Feb 4, 2014·Kidney International·Juan Camilo Duque, Roberto I Vazquez-Padron
Jul 24, 2012·Seminars in Vascular Surgery·Michael S Conte
Jul 24, 2012·Seminars in Vascular Surgery·Fernando Gallardo PedrajasPeter A Schneider
Nov 26, 2015·Journal of Vascular Surgery·Jessica P SimonsUNKNOWN Society for Vascular Surgery Vascular Quality Initiative
Jul 28, 2012·Annals of Vascular Surgery·Katja B C SchampClark J Zeebregts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.