Results of renal transplantation in patients with renal cell carcinoma and von Hippel-Lindau disease

Transplantation
D A GoldfarbA C Novick

Abstract

Patients with von Hippel-Lindau (VHL) disease are at risk for the development of end-stage renal failure from the treatment of localized renal cell carcinoma. Transplantation with its attendant immunosuppression may predispose patients to tumor recurrence; however, there is little information regarding the outcome with this approach. In this article, we review the North American and European experience with renal transplantation in this patient population. The study group comprises 32 patients who have VHL rendered anephric secondary to localized renal cell carcinoma and who have undergone renal transplantation. Patients were identified from North American (n=18) and European (n=14) registries. The outcome of the study group is compared with a cohort of 32 renal transplant recipients without VHL from the Cleveland Clinic Unified Transplant Data Base, who were matched for donor source, gender, age, transplant status (primary vs. regraft), and date of transplantation. The 23 men and 9 women in the study group received transplants between 1974 and 1996. The average age at transplantation was 36 years, and the average duration of dialysis before transplantation was 26 months. Patients have been followed for 48+/-35 months. There wa...Continue Reading

References

Jul 1, 1977·Archives of Surgery·G J PetersonW T Newton
Oct 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·H P NeumannP Schollmeyer
Jun 1, 1995·The Journal of Urology·F SteinbachJ B deKernion
Mar 1, 1993·The Journal of Urology·M FrydenbergH Zincke
Jan 1, 1997·Kidney International·H P Neumann, B Zbar

❮ Previous
Next ❯

Citations

Jul 4, 2001·The Journal of Urology·R G Uzzo, A C Novick
Mar 10, 2011·European Journal of Human Genetics : EJHG·Eamonn R MaherStéphane Richard
Feb 14, 2006·Nature Clinical Practice. Urology·Robert L GrubbMcClellan M Walther
Jul 31, 2013·Nature Reviews. Nephrology·Birke BauschHartmut P H Neumann
Mar 27, 1999·European Journal of Clinical Investigation·F J HesC J Lips
Aug 13, 2008·Advances in Urology·Jorge Hidalgo, Gilberto Chéchile
May 27, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Rohit JoshiBasant Pawar
Jul 12, 2014·Current Opinion in Urology·Adam R Metwalli, William M Linehan
Dec 24, 2013·Advances in Chronic Kidney Disease·Naomi B Haas, Katherine L Nathanson
Oct 23, 2012·The Journal of Urology·Eric A SingerGennady Bratslavsky
Jun 5, 2012·Seminars in Cancer Biology·Stéphane RichardSophie Gad
Apr 11, 2012·The Urologic Clinics of North America·Brian ShuchGennady Bratslavsky
May 19, 2010·The Journal of Urology·Gopal N GuptaGennady Bratslavsky
Nov 11, 2008·The Urologic Clinics of North America·Carvell T NguyenAndrew C Novick
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Martin ZeierEberhard Ritz
Apr 4, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Claudia E FalkensammerJustin H Nguyen
Aug 11, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J H KaoukD Goldfarb
Feb 3, 2005·Transplantation Proceedings·R E PowerD M Little
Jun 18, 2004·The Journal of Urology·Branden G DuffeyMcClellan M Walther
Dec 6, 2008·Surgical Oncology Clinics of North America·Amanda Beth Reed, Dipen J Parekh
Apr 1, 2016·Nature Reviews. Clinical Oncology·Xavier M KeutgenElectron Kebebew
Jan 31, 2002·Annual Review of Medicine·Andrew C Novick
Oct 30, 2019·Orphanet Journal of Rare Diseases·Patrick SchuhmacherStefan Zschiedrich
Jan 26, 2021·Clinical Case Reports·Elisa K BongettiMathew C Mathew
May 5, 2021·Expert Opinion on Investigational Drugs·Elshad Hasanov, Eric Jonasch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.