PMID: 3756409Aug 1, 1986Paper

Results of surgery following radical radiotherapy for invasive bladder cancer

British Journal of Urology
P M QuiltyD A Tolley

Abstract

Five hundred and ninety-one of 889 patients with T1 to T4 transitional cell carcinoma of the bladder had persistent or recurrent cancer after radical radiotherapy. Durable local control was significantly poorer for patients with grade 1 or T4 cancer before radiotherapy. Three hundred and twenty-two patients received additional surgical treatment: 211 were endoscopically managed and 111 had secondary cystectomy. The survival of patients with residual or recurrent cancer after radiotherapy was significantly improved by secondary local treatment (P less than 0.0001). A comparison was made between endoscopic treatment and cystectomy after radiotherapy. Patients having secondary cystectomy were younger (mean age 60.0 years) than those managed endoscopically (66.8 years). The 5-year actuarial survival rate (from the date of radiotherapy) for patients who had endoscopic treatment was 47.1% compared with 62.5% for those who had cystectomy (P = 0.16). After both treatments survival was significantly correlated with the T category of the tumour before radiotherapy. Local tumour control was better after cystectomy; 85.6% of patients were locally tumour-free at the end of follow-up compared with 44.5% of those managed endoscopically. There...Continue Reading

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Citations

May 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A N ScholtenA Timothy
Jul 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L SengeløvH von der Maase
Nov 30, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L Sengeløv, H von der Maase
Dec 29, 1999·International Journal of Radiation Oncology, Biology, Physics·C R HayterW J Mackillop
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D PectasidesA Athanassiou
Feb 1, 1992·British Journal of Urology·J WaxmanP Abel
Dec 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Duncan, P M Quilty
Feb 7, 2007·Urology·Michael MilosevicWilliam Shipley
Aug 21, 2013·International Journal of Cancer. Journal International Du Cancer·Karen J BowmanGeorge D D Jones
Jan 1, 1993·Cancer Treatment Reviews·J Waxman, C Barton
Feb 1, 2006·Expert Review of Anticancer Therapy·Lars FokdalHans von der Maase
Dec 17, 2003·British Journal of Cancer·M A L MoneefG D D Jones
Jan 19, 2001·Angewandte Chemie·Erich SteinerLeonardus W Jenneskens
Jan 1, 1988·Scandinavian Journal of Urology and Nephrology·P Rosenkilde OlsenK Højgaard
Nov 5, 2015·American Journal of Clinical Oncology·Jung J KangChristopher R King
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Jan 1, 1989·Seminars in Surgical Oncology·Z Wajsman, I W Klimberg
Aug 29, 2000·BJU International·A D MacVicar

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