Results of tests for possible transmitted genetic effects of hycanthone in mammals

Journal of Toxicology and Environmental Health
W L Russell

Abstract

Extensive tests to detect transmitted genetic effects of hycanthone in mammals have been made to provide the most pertinent information for estimating a possible mutagenic hazard of this compound. The tests include dominant lethal studies in males and females, X chromosome loss study in offspring of treated females, and a search for deficiencies and gene mutations in the offspring of treated males whose germ cells were exposed in spermatogonial and postspermatogonial stages. In most tests, no genetic effect of hycanthone was observed even at dosages much higher than the clinical level. In the few cases where the results are possibly or definitely positive, there is none where the magnitude of the effect estimated, with maximizing assumptions, at the clinical level reaches as high as 10% of the spontaneous mutation rate or 10% of the frequency in controls.

Citations

Sep 21, 1977·Archives of Toxicology·W L Russell
Nov 1, 1980·Archives of Toxicology·U H Ehling
Nov 1, 1984·Mutation Research·W M GenerosoJ C Rutledge
Jan 1, 1995·Pharmacology & Therapeutics·D CioliS Archer
Aug 1, 1986·Mutation Research·F J de Serres
Jan 1, 1987·Environmental and Molecular Mutagenesis·R Albanese
Jun 1, 1976·The Australian Journal of Physiotherapy·M A SteinbergJ Rendle-Short

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.