Results of the multicenter RENEWAL 3 AVT clinical study of cardiac resynchronization defibrillator therapy in patients with paroxysmal atrial fibrillation

Journal of Cardiovascular Electrophysiology
Leslie A SaxonRhonda VAN Genderen


Atrial fibrillation impacts the clinical course of up to 50% of patients with advanced heart failure (HF) who are eligible for cardiac resynchronization therapy with a defibrillator (CRT-D). While RV-based defibrillators are available with advanced atrial diagnostics and therapies that provide rapid diagnosis and treatment of spontaneously occurring atrial tachycardia/fibrillation (AT/AF) episodes, there is no CRT-D device that combines atrial/ventricular and CRT therapies. The purpose of the prospective multicenter RENEWAL 3 AVT study is to assess the performance of atrial diagnostics and therapies used in combination with a CRT-D device. Enrolled patients were required to have indications for a CRT-D device and a documented episode of AT/AF within 12 months of enrollment. A total of 170 patients were enrolled over 9 months (85% male; mean age 72 +/- 10 years; NYHA classification: 88% III, 12% IV; left ventricular ejection fraction [LVEF] mean 23 +/- 6%; mean QRS duration 150 +/- 25 msec; 78% ischemic etiology). The documented atrial arrhythmia was AF in 77% of patients. A total of 60% of patients had the CRT-D device placed for primary prevention of sudden death and 40% of patients had a history of ventricular arrhythmia in a...Continue Reading

Associated Clinical Trials


Oct 1, 1993·Journal of the American College of Cardiology·R GargS Yusuf
Feb 7, 2002·JAMA : the Journal of the American Medical Association·Anju NohriaLynne Warner Stevenson
May 27, 2003·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Irina Savelieva, A John Camm
May 29, 2003·JAMA : the Journal of the American Medical Association·James B YoungUNKNOWN Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE ICD) Trial Investigators
Jan 24, 2004·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Renato RicciMassimo Santini
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators

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May 2, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Antoine LeenhardtUNKNOWN OPERA Registry Investigators
Aug 15, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Pietro TurcoAntonio De Simone
Nov 27, 2015·Future Cardiology·Luca Santini, Massimo Santini
Dec 7, 2007·The Medical Clinics of North America·Gautham Kalahasty, Kenneth Ellenbogen
Jan 15, 2009·Pacing and Clinical Electrophysiology : PACE·George H CrossleyUNKNOWN Concerto-AT Study Investigators

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