Results of the screening program for congenital hypothyroidism in Berlin (1978-1995)

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
A GrütersU Lehmkuhl

Abstract

Screening for congenital hypothyroidism for all newborns of the former western parts of the city of Berlin was instituted in 1978 by determination of the TSH levels in dried filter paper blood spots of the 3rd to 5th day of life. Since 1991 the newborns of the former eastern parts have been also included in the same screening program. From 1978 to 1995 a total number of 104 newborns with permanent congenital hypothyroidism have been detected resulting in a prevalence of congenital hypothyroidism of 1:3800. The etiological diagnosis of hypothyroidism was made by imaging studies (ultrasonography or 99mTc scintigraphy) and assessment of serum thyroglobulin and thyroid hormone levels. Using this approach in 37 children (30 female, 7 male) the diagnosis of athyrosis, in 20 children (15 female, 5 male) the diagnosis of ectopy and in 21 children (18 female, 3 male) the diagnosis of thyroid hypoplasia was made, 16 children (8 female, 8 male) had a normally sized gland and 4 (1 female, 3 male) had congenital goiter. In 86% of all patients the age at onset of thyroxine (L-T4) replacement therapy was 8 or 9 days of life (3-42 days) and the median initial L-T4 dose was 14 micrograms/kg/day (10-16 micrograms/kg/day). The intellectual outcom...Continue Reading

Citations

Oct 16, 2003·Thyroid : Official Journal of the American Thyroid Association·Meyer Knobel, Geraldo Medeiros-Neto
Dec 4, 2003·Thyroid : Official Journal of the American Thyroid Association·Sonja Heyerdahl, Beate Oerbeck
Feb 6, 2002·Archives of Disease in Childhood·P C Hindmarsh
Dec 17, 2005·Journal of Zhejiang University. Science. B·Ru-lai YangZheng-yan Zhao
Jun 18, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·Annette GrütersHeiko Krude
Sep 7, 2012·Case Reports in Endocrinology·Rita Ann KubickyFrancesco De Luca
Jan 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Juliane LégerUNKNOWN Congenital Hypothyroidism Consensus Conference Group
Jan 24, 2019·Journal of Innovation in Health Informatics·Haleh AyatollahiMaryam Ahmadi
Sep 13, 2008·Pediatric Research·Anastasia DimitropoulosBeatrice Latal
Aug 30, 2018·Hormone Research in Pædiatrics·Giovanni PreziosoFrancesco Chiarelli

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