Results of the treatment of syringomyelia associated with Chiari malformation: analysis of 60 cases

Arquivos de neuro-psiquiatria
José Arnaldo Motta de ArrudaOswaldo Inácio de Tella

Abstract

We analyze the results of surgical treatment of 60 patients presenting syringomyelia (SM) associated with Chiari malformation (CM) who were operated in the period 1982-2000. For each case, analysis covered 15 signs and 16 symptoms included in a protocol that separated SM signs and symptoms from those of CM. A score system was established in parallel with the protocol to make the evaluation of treatment results easier. All cases were submitted to craniovertebral decompression by C1 and eventually C2 laminectomy and cerebellar tonsillectomy with duramater graft. To evaluate the results, statistical proportion difference tests and variance analyses were made to a reliability index of 95% (p=0.05). We conclude that the statistical improvement of CM signs and symptoms was very significant (p=0). Syringomyelia signs and symptoms also improved significantly, except for "upper limb hyporeflexia", which did not improve. No statistical difference in the improvement of SM symptoms as compared to CM symptom was found. Syringomyelia signs improved statistically more than CM signs. In half of patients, the percent improvement of signs and symptoms ranged between 40% and 60%.

References

Jun 1, 1978·Brain : a Journal of Neurology·B Williams
Oct 1, 1989·Surgical Neurology·T Matsumoto, L Symon
Nov 1, 1972·Journal of Neurosurgery·P W Carmel, W R Markesbery
Dec 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·M Caetano de BarrosS Lins
Apr 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·V Logue, M R Edwards
Dec 1, 1995·Neurosurgery·A K BindalJ M Tew
Aug 2, 2003·Arquivos de neuro-psiquiatria·José Alberto Gonçalves da Silva, Maurus Marques de Almeida Holanda
Mar 1, 1956·Arquivos de neuro-psiquiatria·H M CANELASO R CRUZ
Jan 1, 1958·Clinical Neurosurgery·W J GARDNER, J ANGEL
May 9, 2006·Neurosurgical Focus·D R TodorT H Milhorat

❮ Previous
Next ❯

Citations

Feb 24, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·R Prat, I Galeano
Nov 8, 2014·Journal of Neurosurgery·Jacob K GreenbergDavid D Limbrick
Oct 22, 2013·Arquivos de neuro-psiquiatria·José Alberto Gonçalves da SilvaEverardo Bandeira de Almeida
Nov 2, 2011·Arquivos de neuro-psiquiatria·José Alberto Gonçalves da SilvaGiseuda Pessoa Regueira
Nov 23, 2006·Arquivos de neuro-psiquiatria·José Alberto Gonçalves da SilvaAndré Pachelli Bezerra Viana
Oct 24, 2007·Arquivos de neuro-psiquiatria·Andre Carvalho FelícioHenrique Ballalai Ferraz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.