Results of the Zometa cost-utility model for the german healthcare system based on the results of the ABCSG-12 study

Onkologie
Michael P LuxFalk C Thiel

Abstract

The ABCSG-12 trial investigated the efficacy of gonadotropin-releasing hormone (GnRH)analogs in combination with tamoxifen or anastrozole + or - zoledronic acid (4 mg, q6m for 3 years) in 1,803 premenopausal women with hormone receptor-positive (HR+) breast cancer. After 48 months of follow-up, there was a 36% improvement in the disease-free survival (DFS) (recurrence-free survival 35%) using zoledronic acid. Based on these data, the costutility of zoledronic acid was calculated for the German healthcare system. Costs of surveillance, adverse effects, recurrence, contralateral breast cancer, metastasis, and end-of-life care were determined based on the Einheitlicher Bewertungsmabetastab (EBM 2009) and the diagnosis-related groups (DRG) system. Utilities were surveyed with a questionnaire (n = 95). Estimation of the cost-utility was made by calculating the incremental costeffectiveness ratio (ICER) per quality-adjusted life year (QALY), using a Markov model. Including zoledronic acid as adjuvant therapy for 3 years resulted in total costs of euro 2,262. The use of zoledronic acid is dominant when clinical efficacy and quality of life are taken into consideration (- euro 45.83/QALY) (95% confidence interval (CI) - euro 1,838 to E...Continue Reading

Citations

Nov 5, 2015·Journal of Comparative Effectiveness Research·Georg RuileUNKNOWN National Leading-Edge Cluster Medical Technologies ‘Medical Valley EMN’
Aug 31, 2016·Breast Cancer Research and Treatment·Virginie NerichBernhard Holzner
Apr 7, 2017·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Dirk MüllerStephanie Stock

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