PMID: 9168301Apr 1, 1997Paper

Results of three courses of adriamycin, bleomycin, vindesine, and dacarbazine with subtotal nodal irradiation in 189 patients with nodal Hodgkin's disease (stage I, II and IIIA)

Hematology and Cell Therapy
M AndréC Gisselbrecht

Abstract

To evaluate in a prospective trial three courses of an ABVD-like chemotherapy (CT) regimen given before radiation therapy (RT) (subtotal nodal irradiation (STNI) in favorable stage Hodgkin's disease (HD). The efficacy, risk factors and medium-term toxicities are reported. Stage I or II with at least one of the following factors, mediastinal involvement, histological type 3, age > 40 years, ESR rate > 50 mm, or stage IIIA. 189 patients with newly diagnosed HD were treated between 01/89 and 01/94 (stage I, n = 33; stage II, n = 129, stage IIIA, n = 27). Three courses of an ABVD-like regimen (adriamycin 25 mg/m2, bleomycin 10 mg, vindesine 2 mg/m2 and dacarbazine 250 mg/m2 day 1 and 8) were given before STNI at 36/40 grays. At diagnosis, prognostic factors were distributed as follows: B symptoms (n = 54), bulky mediastinum (n = 41), hemoglobin < 12 g/dl (n = 37), ESR > 50 (n = 65), age > 45 (n = 24). After chemotherapy, 90% had an objective response (partial response > 75%) and 98% were in complete remission (CR) at the end of RT. Three patients had primary refractory disease and 13 patients (7%) relapsed, 3 at the initial site, 4 at previously uninvolved sites and 6 at both. With a median follow-up of 60 months, 170 patients are ...Continue Reading

Citations

Aug 29, 2003·Current Treatment Options in Oncology·Andreas Josting, Volker Diehl
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Andrea K NgPeter M Mauch
Aug 9, 2016·Seminars in Hematology·Andreas Engert, John Raemaekers
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karolin BehringerUNKNOWN German Hodgkin's Lymphoma Study Group
Oct 13, 2006·Hematological Oncology·David C HodgsonMary K Gospodarowicz
Apr 19, 2019·Annals of Hematology·Francesco GaudioGiorgina Specchia
Feb 13, 2016·Molecular and Clinical Oncology·Ignacio García EscobarMariano Provencio Pulla

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