Abstract
To evaluate the effectiveness of three-dimensional conformal radiotherapy and thalidomide in the treatment of advanced hepatocellular carcinoma. Between 1999 and 2003, 121 patients (mean age, 54.4 +/- 12.4 years; range, 20-81 years) with advanced hepatocellular carcinoma received three-dimensional conformal radiotherapy and thalidomide. Radiation was delivered in 1.5 Gy fractions twice daily for 5 days a week, for a total dose of 45-75 Gy. Mean treatment volume was 429.52 +/- 408.50 cm(3) (range, 26.89-2284.82 cm(3)). Thalidomide was given concomitantly: 200 mg/day in 109 patients, 300 mg/day in 8 patients and 400 mg/day in 4 patients. Treatment responses, survival rates and factors affecting survival were analyzed. Treatment responses were observed in 61% of the patients. Liver cirrhosis (P = 0.001) and tumor size (P = 0.001) significantly affected the tumor responses. Overall survival at 6, 12 and 24 months was 84.8, 60.0 and 44.6%, respectively. On univariate analysis, liver cirrhosis (P = 0.003), Karnofsky performance status (P = 0.007), tumor size (P < 0.001), portal vein tumor thrombosis (P < 0.001) and alpha-fetoprotein level (P = 0.003) were shown to significantly affect survival. On multivariate analysis, only thrombos...Continue Reading
References
Aug 1, 1992·American Journal of Clinical Oncology·V DhirL J Desouza
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·T S LawrenceW D Ensminger
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Okuda
Mar 1, 1988·Annals of Internal Medicine·A M Di BisceglieM T Lotze
May 4, 1989·Nature·J FolkmanD Hanahan
Dec 1, 1989·International Journal of Radiation Oncology, Biology, Physics·G B StillwagonE K Fishman
Sep 1, 1987·The British Journal of Surgery·T Y LinC C Chen
Aug 15, 1985·Cancer·K OkudaK Ohnishi
Jun 1, 1980·Journal of the National Cancer Institute·P J Johnson, R Williams
Jan 1, 1982·Cancer Chemotherapy and Pharmacology·P A VolberdingT L Phillips
Jul 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M RobertsonW D Ensminger
Jun 1, 1996·Cancer·K E StuartR L Jenkins
Aug 9, 1996·Cell·D Hanahan, J Folkman
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·J M RobertsonW D Ensminger
Apr 1, 1997·American Journal of Surgery·C L Liu, S T Fan
Jan 4, 1998·Journal of Gastroenterology and Hepatology·C J ChenY F Liaw
Feb 25, 1999·International Journal of Radiation Oncology, Biology, Physics·J SeongG E Kim
Oct 26, 1999·Journal of Gastroenterology and Hepatology·S H ChengJ L Sung
Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Jan 5, 2000·Cancer·L LladóE Jaurrieta
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Apr 27, 2000·The American Journal of Medicine·L Calabrese, A B Fleischer
May 10, 2000·International Journal of Radiation Oncology, Biology, Physics·J C ChengC F Horng
Jun 26, 2001·Journal of Gastroenterology and Hepatology·J TazawaC Sato
Oct 11, 2001·British Journal of Cancer·J StebbingM E Gore
Jan 31, 2002·Annual Review of Medicine·Paul RichardsonKenneth Anderson
Mar 22, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S Singhal, J Mehta
May 31, 2002·Blood·Nicholas MitsiadesKenneth C Anderson
Jan 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Jinsil SeongChae Yoon Chon
Dec 6, 2003·Oncology·Chiun HsuAnn-Lii Cheng
Jul 22, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas K EigentlerClaus Garbe
Citations
Apr 18, 2013·Surgery Today·Satoshi Katagiri, Masakazu Yamamoto
Aug 5, 2010·Journal of Gastrointestinal Cancer·Anne M HorganJennifer J Knox
Apr 3, 2009·Chemical Reviews·Philip J Tofilon, Kevin Camphausen
Apr 24, 2012·Nutrition and Cancer·Wei-Chung HsuNa-Na Chung
Dec 12, 2012·Radiation Oncology·Po-Ming WangLuca Cozzi
Feb 1, 2008·Annals of Surgical Oncology·Sunil KrishnanFrancoise Mornex
Dec 17, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Shinji SugaharaKoichi Tokuuye
Dec 24, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Po-Ming WangMarta Scorsetti
May 2, 2009·International Journal of Radiation Oncology, Biology, Physics·Min-Hua WangYun-Shan Tan
Nov 21, 2009·Technology in Cancer Research & Treatment·Abdul Aziz Al HamadDavid Roberge
Jan 11, 2012·Oncology·Ik Jae Lee, Jinsil Seong
Apr 9, 2008·The Cancer Journal·Laura A Dawson, Chandan Guha
Nov 3, 2009·Yonsei Medical Journal·Jinsil Seong
Dec 16, 2006·World Journal of Gastroenterology : WJG·Masami Minagawa, Masatoshi Makuuchi
Mar 1, 2016·International Journal of Particle Therapy·Masashi MizumotoHideyuki Sakurai
Sep 10, 2019·World Journal of Gastroenterology : WJG·Lucia CerritoFrancesca Romana Ponziani