PMID: 9006523Jan 1, 1997Paper

Resumption of menses in anorexia nervosa

Archives of Pediatrics & Adolescent Medicine
N H GoldenI R Shenker

Abstract

To determine factors associated with resumption of menses (ROM) in adolescents with anorexia nervosa. Cohort study with 2-year follow-up. Tertiary care referral center. Consecutive sample of 100 adolescent girls with anorexia nervosa. Body weight, percent body fat, and luteinizing hormone, follicle-stimulating hormone, and estradiol levels were measured at baseline and every 3 months until ROM (defined as 2 or more consecutive spontaneous menstrual cycles). Treatment consisted of a combination of medical, nutritional, and psychiatric intervention aimed at weight gain and resolution of psychological conflicts. Body weight, body composition, and hormonal status at ROM. Menses resumed at a mean (+/-SD) of 9.4 +/- 8.2 months after patients were initially seen and required a weight of 2.05 kg more than the weight at which menses were lost. Mean (+/-SD) percent of standard body weight at ROM was 91.6% +/- 9.1%, and 86% of patients resumed menses within 6 months of achieving this weight. At 1-year follow-up, 47 (68%) of 69 patients had resumed menses and 22 (32%) remained amenorrheic. No significant differences were seen in body weight, body mass index, or percent body fat at follow-up in those who resumed menses by 1 year compared wi...Continue Reading

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