Resumption of menses with initiation of letrozole after five years of amenorrhea on tamoxifen: caution needed when using tamoxifen followed by aromatase inhibitors

Cancer Investigation
Jeffrey B Hargis, Steven T Nakajima

Abstract

Randomized trials in postmenopausal women have shown a benefit to substituting aromatase inhibitors for tamoxifen or using them sequentially following a full course of tamoxifen. The aromatase inhibitor letrozole has also been utilized for ovarian induction in premenopausal women. A premenopausal woman with early stage breast cancer became amenorrheic with adjuvant chemotherapy, and remained so during 5 years of daily tamoxifen. After discontinuing tamoxifen, laboratory studies confirmed an apparent postmenopausal state. Menses resumed following a 2-week course of letrozole. Aromatase inhibitors need to be used with caution in women who stop menstruating following adjuvant chemotherapy or tamoxifen.

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Citations

Nov 28, 2008·The Breast : Official Journal of the European Society of Mastology·Olaf OrtmannHans Wildiers
May 22, 2007·Hematology/oncology Clinics of North America·Per Eystein Lønning
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Aug 8, 2013·Aging & Mental Health·Kun Liang
Feb 18, 2011·Menopause : the Journal of the North American Menopause Society·Anne-Sophie DieudonnéPatrick Neven

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