Resuscitating the heart but losing the brain: brain atrophy in the aftermath of cardiac arrest

Neurology
A HorstmannM L Schroeter

Abstract

Many survivors of cardiac arrest are left with considerable long-term impairments due to a transient ischemic state of the brain. Neuropsychologists identified a wide range of neuropsychological deficits in these patients besides the well-known amnesic syndrome. To date, there is no complete and unbiased documentation of the affected brain areas in vivo. We aimed to identify the brain tissue atrophy underlying the observed neuropsychological deficits in a case-control study. We measured gray matter loss by voxel-based morphometry of 3-T structural magnetic resonance images in a sample of 12 patients who had had cardiac arrest with successful subsequent resuscitation in comparison with 12 individually age- and sex-matched control subjects. Such data are rare because many of these patients wear cardiac pacemakers. We found extensive reductions of gray matter volumes in the anterior, medial, and posterior cingulate cortex, the precuneus, the insular cortex, the posterior hippocampus, and the dorsomedial thalamus in tight correlation with neuropsychological impairments, namely, amnestic deficits and apathy. The identified neuroanatomical pattern of brain tissue loss substantiates the reports of wide-ranging neuropsychological impai...Continue Reading

Citations

Oct 29, 2010·Neurocase·M Di PaolaG A Carlesimo
Mar 2, 2012·Journal of Clinical and Experimental Neuropsychology·Lindsay A MillerJohn Gunstad
Mar 10, 2012·The Clinical Neuropsychologist·David E WarrenDaniel Tranel
Dec 15, 2010·Stroke; a Journal of Cerebral Circulation·Randolph S Marshall, Ronald M Lazar
Sep 27, 2014·Critical Care Clinics·Matthew A Koenig
Sep 23, 2014·Nature Reviews. Neuroscience·Bryan A StrangeEdvard I Moser
May 25, 2013·Neuroscience and Biobehavioral Reviews·Ivar ReinvangLars Tjelta Westlye
Jun 15, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideaki SuzukiHiroaki Shimokawa
Dec 10, 2016·Hippocampus·Cassidy M FifordUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 31, 2018·Frontiers in Neurology·Sazuku NisitaniYoji Katsuoka
Dec 20, 2017·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Stefan FrischRegina Tina Jentzsch
Mar 14, 2012·Nature Reviews. Neurology·Majid FotuhiClifford Jack
Oct 28, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Behnam SabayanLenore J Launer
Apr 14, 2019·Neurorehabilitation and Neural Repair·Marte C ØrboTorgil R Vangberg
Sep 12, 2013·The Journal of Pharmacology and Experimental Therapeutics·Travis C JacksonPatrick M Kochanek
Jan 24, 2020·Circulation Research·Karsten MuellerMatthias L Schroeter
Jan 18, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Satoshi TsuchiyaHiroaki Shimokawa
Jun 6, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nancy TsengD Ryan Ormond
Jun 7, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Charles H CohanMiguel A Perez-Pinzon
Jan 25, 2018·Acta Anaesthesiologica Scandinavica·E WallinS Rubertsson
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Virginie BolducEric Thorin
May 14, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Piotr Gałecki, Monika Talarowska
Nov 30, 2018·Journal of Neuroscience Research·Varun KumarWen-Hai Chou
Oct 17, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohammad NasehiMohammad-Reza Zarrindast
May 26, 2017·Current Treatment Options in Cardiovascular Medicine·Carolina B MacielDavid M Greer
Dec 26, 2018·Journal of Alzheimer's Disease : JAD·Iris EscobarMiguel A Perez-Pinzon
Aug 31, 2021·Oxidative Medicine and Cellular Longevity·Chengyang XuZhipeng Cao
Oct 8, 2021·Seminars in Neurology·Elizabeth Carroll, Ariane Lewis

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