Jan 1, 2013

Resuscitation after hemorrhagic shock: the effect on the liver--a review of experimental data

Journal of Anesthesia
Iosifina I KarmaniolouNikolaos F Arkadopoulos

Abstract

The liver is currently considered to be one of the first organs to be subjected to the hypoxic insult inflicted by hemorrhagic shock. The oxidative injury caused by resuscitation also targets the liver and can lead to malfunction and the eventual failure of this organ. Each of the various fluids, vasoactive drugs, and pharmacologic substances used for resuscitation has its own distinct effect(s) on the liver, and the anesthetic agents used during surgical resuscitation also have an impact on hepatocytes. The aim of our study was to identify the specific effect of these substances on the liver. To this end, we conducted a literature search of MEDLINE for all types of articles published in English, with a focus on articles published in the last 12 years. Our search terms were "hemorrhagic shock," "liver," "resuscitation," "vasopressors," and "anesthesia." Experimental studies form the majority of articles found in bibliographic databases. The effect of a specific resuscitation agent on the liver is assessed mainly by measuring apoptotic pathway regulators and inflammation-induced indicators. Apart from a wide range of pharmacological substances, modifications of Ringer's Lactate, colloids, and pyruvate provide protection to the l...Continue Reading

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Mentioned in this Paper

Biochemical Pathway
Pyruvate Measurement
Organ
Etiology
Pyruvate
Liver Diseases
Body Fluids
Absence of Sensation
Inflammation
Late-onset Congenital Adrenal Hyperplasia

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