PMID: 9555846Apr 29, 1998Paper

Resuscitation after uncontrolled venous hemorrhage: Does increased resuscitation volume improve regional perfusion?

The Journal of Trauma
N SmailI H Chaudry

Abstract

Recent studies have questioned the use of aggressive fluid resuscitation after uncontrolled arterial hemorrhage until the bleeding is controlled. However, it remains unknown whether resuscitation after hemorrhage from a venous origin (usually nonaccessible to surgical intervention) has any beneficial or deleterious effects on regional perfusion. The aim of this study, therefore, was to determine whether increased volume of fluid resuscitation after uncontrolled venous hemorrhage improves hemodynamic profile and regional perfusion in various tissues. After methoxyflurane anesthesia and midline laparotomy, both lumbar veins in the rat were severed, which resulted in lowering the mean arterial blood pressure to approximately 40 mm Hg. This pressure was maintained for 45 minutes by allowing further bleeding from the lumbar veins. The abdominal incision was then closed in layers and the animals received either 0, 10, or 30 mL of lactated Ringer's solution intravenously over a period of 60 minutes. Cardiac output and regional blood flow were determined by radioactive microspheres immediately or at 1.5 hours after the completion of resuscitation. Fluid resuscitation with 10 or 30 mL lactated Ringer's solution increased mean arterial b...Continue Reading

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Citations

May 29, 1999·AACN Clinical Issues·W J Robb
Jan 24, 2002·Current Opinion in Critical Care·S A Stern
Jun 11, 2002·International Anesthesiology Clinics·Richard P Dutton
Jun 5, 2002·The Journal of Trauma·Richard P DuttonThomas M Scalea
Oct 4, 2006·Current Opinion in Anaesthesiology·W F Dick, W Mauritz
Mar 18, 2008·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Lynn Schweer
Jan 22, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jean-Michel YeguiayanUNKNOWN French Intensive Care Recorded In Severe Trauma Study Group
Dec 24, 2005·Shock·J L Lomas-NieraAlfred Ayala
Feb 1, 2007·Journal of Trauma Nursing : the Official Journal of the Society of Trauma Nurses·Kathryn M Moore
Dec 24, 2004·Current Opinion in Critical Care·Robert N BilkovskiH Matilda Horst
Feb 9, 2012·Emergency Medicine Australasia : EMA·Anthony HolleyJeffrey Lipman
Nov 19, 2005·The Journal of Trauma·Stephanie A SavageJeffrey D Kerby
Jan 9, 2004·Clinics in Chest Medicine·Cheryl L Holmes, Keith R Walley
Jan 5, 2002·The Surgical Clinics of North America·M OrlinskyM D Kerstein

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