Resuscitation and perioperative management of the high-risk single ventricle patient: first-stage palliation

Congenital Heart Disease
Adam W Lowry


Infants born with hypoplastic left heart syndrome or other lesions resulting in a single right ventricle face the highest risk of mortality among all forms of congenital heart disease. Before the modern era of surgical palliation, these conditions were universally lethal; recent refinements in surgical technique and perioperative management have translated into dramatic improvements in survival. Nonetheless, these infants remain at a high risk of morbidity and mortality, and an appreciation of single ventricle physiology is fundamental to the care of these high-risk patients. Herein, resuscitation and perioperative management of infants with hypoplastic left heart syndrome are reviewed. Basic neonatal and pediatric life support recommendations are summarized, and perioperative first-stage clinical management strategies are reviewed.


Jul 1, 1976·American Heart Journal·M R NihillR L Vick
May 1, 1972·The American Journal of Physiology·T RomeroW F Friedman
Jan 6, 1983·The New England Journal of Medicine·W I NorwoodD D Hansen
Nov 1, 1994·Journal of the American College of Cardiology·O BarneaW P Santamore
Oct 15, 1995·The American Journal of Cardiology·H P Gutgesell, T A Massaro
Jun 1, 1994·Anesthesia and Analgesia·V C Baum, G T Wetzel
Jul 1, 1996·The Annals of Thoracic Surgery·C J RiordanE H Austin
Mar 1, 1997·The Annals of Thoracic Surgery·C J RiordanE H Austin
Mar 13, 1998·Archives of Disease in Childhood·S M TibbyI A Murdoch
Mar 23, 1999·The Annals of Thoracic Surgery·J S TweddellS B Litwin
May 20, 1999·European Journal of Pediatrics·E L DuvalC J Heijnen
Jul 16, 1999·The Journal of Maternal-fetal Medicine·M B MunnE V Colvin
Aug 5, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·E MalecJ Pajak
Aug 30, 2000·Pacing and Clinical Electrophysiology : PACE·J JanousekO Reich
Mar 30, 2001·The Journal of Thoracic and Cardiovascular Surgery·P M VerheijenG B Bennink
Apr 13, 2001·Journal of the American College of Cardiology·C A WarnesG D Webb
Jul 5, 2001·Current Opinion in Critical Care·E P RiversD Powell
Oct 3, 2001·International Anesthesiology Clinics·K K GalliS C Nicolson
Oct 11, 2001·Critical Care Medicine·D L Wessel
Jan 16, 2002·The Annals of Thoracic Surgery·S M BradleyA M Atz
May 1, 2002·The Thoracic and Cardiovascular Surgeon·H Abdul-KhaliqP E Lange
Jun 27, 2002·Journal of the American College of Cardiology·Julien I E Hoffman, Samuel Kaplan
Jul 10, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J William GaynorThomas L Spray
Dec 24, 2002·Archives of Disease in Childhood·S M Tibby, I A Murdoch
Jul 10, 2003·Critical Care Clinics·Steven M SchwartzDavid P Nelson
Feb 1, 1965·Circulation Research·D E GREGGC R RAYFORD
Feb 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Scott M BradleyJanet M Simsic
Mar 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·George M HoffmanStuart Berger

❮ Previous
Next ❯


Apr 25, 2018·Circulation·Bradley S MarinoUNKNOWN American Heart Association Congenital Cardiac Defects Committee of the Council on Cardiovascular Disease in the Young; Counc
Nov 20, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nicola MaschiettoDiego Porras
Jun 22, 2018·Frontiers in Pediatrics·Peter C Laussen, Anne-Marie Guerguerian
Jul 4, 2021·Emergency Medicine Clinics of North America·Ashley M Strobel, Leen Alblaihed

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved