PMID: 15377891Sep 21, 2004Paper

Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin

Shock
Reto WettsteinMarcos Intaglietta

Abstract

Our aim was to determine the efficacy of polyethylene glycol-conjugated human albumin (MalPEG-Alb) in restoring circulatory volume after 1 h of hemorrhagic shock. Experiments were performed in the awake condition in the hamster skin fold preparation. Microhemodynamic parameters and tissue Po2 were assessed with intravital microscopy and the use of the phosphorescence quenching technique. One hour after shock induction by withdrawal of 50% of the blood volume, animals were resuscitated with MalPEG-Alb (n = 6). Systemic and microhemodynamic parameters following resuscitation were identical to those obtained with the same protocol using MalPEG-Hb (1). However, parameters related to microvascular oxygen distribution were significantly lower in the MalPEG-Alb group compared with the previous data from the MalPEG-Hb group in that tissue oxygen partial pressure was 5 +/- 2 mmHg (vs. 8 +/- 3 mmHg, P < 0.05), oxygen delivery was reduced to 60 +/- 27% (P < 0.05), and oxygen consumption was reduced to 69 +/- 28% (P < 0.05). Both molecules were matched in composition (4.2 g/dL) and surface chemistry. MalPEG-Alb colloid osmotic pressure was 37 mmHg (vs. 49 mmHg for MalPEG-Hb), and viscosity was 2.7 cP (vs. 2.5 cP for MalPEG-Hb). The present...Continue Reading

References

Mar 1, 1996·Microvascular Research·I P Torres FilhoM Intaglietta
Feb 1, 1997·The American Journal of Physiology·G WalterJ S Leigh
Jul 1, 1997·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·H NishideE Tsuchida
Feb 12, 2000·Transfusion Medicine Reviews·M D ScottK L Murad
Aug 21, 2001·Clinical Pharmacokinetics·J M HarrisM Modi
Jun 8, 2002·Advanced Drug Delivery Reviews·Francesco M Veronese, J Milton Harris
Jun 8, 2002·Advanced Drug Delivery Reviews·Kenneth D Hinds, Sung Wan Kim
Jun 8, 2002·Advanced Drug Delivery Reviews·Francesco M VeroneseMauro Sergi
Aug 14, 2002·Cancer Treatment Reviews·G Molineux
Aug 14, 2002·Cancer Treatment Reviews·J Crawford
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Hiromi SakaiEishun Tsuchida
Nov 22, 2002·American Journal of Respiratory Cell and Molecular Biology·André M CantinRichard Leduc
Dec 5, 2002·Shock·El Rasheid ZakariaR Neal Garrison
Mar 29, 2003·Transfusion·Kim D VandegriffRobert M Winslow
Apr 19, 2003·Journal of Internal Medicine·R M Winslow
May 10, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Claudio ContaldoDominique Erni
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Amy G TsaiRobert M Winslow
Jul 5, 2003·Physiological Reviews·Amy G TsaiMarcos Intaglietta
Nov 6, 2003·American Journal of Physiology. Cell Physiology·Ashok K GroverSue E Samson

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Citations

Sep 2, 2005·Shock·Ernest E MooreAnirban Banerjee
Nov 2, 2006·Current Opinion in Critical Care·Lauralyn A McIntyre, Paul C Hebert
Feb 14, 2012·Journal of Pharmaceutical and Biomedical Analysis·Rongsheng E WangYie-Hwa Chang
Jan 11, 2012·Molecular Aspects of Medicine·Gabriella FanaliPaolo Ascenzi
Jul 18, 2008·Transfusion·Pedro CabralesMarcos Intaglietta
Jun 1, 2011·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·K AnandaSeetharama A Acharya

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