Resveratrol ameliorates autophagic flux to promote functional recovery in rats after spinal cord injury

Oncotarget
Peng WangZhenming Hu

Abstract

Resveratrol is known to improve functional recovery after spinal cord injury, but the exact mechanism involved is yet unclear. The aim of this study was to clarify whether resveratrol can exert neuroprotective effects via activating neuronal autophagic flux, in view of the underlying role of the autophagic flux mediated by resveratrol on neuronal apoptosis after spinal cord injury, and identify the role of the liver kinase B1(LKB1)/adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/ p70 ribosomal protein S6 kinase (p70s6k) signal pathway in the autophagic flux mediated by resveratrol. The results obtained strongly indicate that resveratrol improved functional recovery in Sprague-Dawley rats after acute spinal cord injury, preserved their motor neurons, alleviated the neuronal apoptosis, and ameliorated neuronal autophagic flux. After blocking the autophagic flux, the neuroprotective effects of resveratrol were eliminated. Furthermore, it was proved that resveratrol can activate the LKB1/AMPK/mTOR/p70s6k pathwayin vivoandin vitro, and the LKB1/AMPK/mTOR/p70s6k pathway plays a vital role in activating the autophagic flux mediated by resveratrol in PC12 cells. Thus, resveratrol enables to ...Continue Reading

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Citations

Mar 10, 2020·BioMed Research International·Brhane Teklebrhan AssefaMeles Tekie Gidey
Jan 17, 2019·Oxidative Medicine and Cellular Longevity·Gloria LazzeriFrancesco Fornai
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Alessandra Stacchiotti, Giovanni Corsetti
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May 17, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Sahib ZadaDeok Ryong Kim

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Methods Mentioned

BETA
transfecting
transfection
electrophoresis
Protein Assay

Software Mentioned

SPSS

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis