Abstract
Resveratrol, a polyphenol found in various plants, including grapes, plums and peanuts has shown various medIRInal properties, including antioxidant, protection of cardiovascular disease and cancer risk. However, the effects of resveratrol on spinal cord reperfusion injury have not been investigated. Hence, the present study was designed to evaluate the effect of resveratrol on nitric oxide synthase (iNOS)/p38MAPK signaling pathway and to elucidate its regulating effect on the protection of spinal cord injury. Spinal cord ischemia-reperfusion injury (IRI) was performed by the infrarenal abdominal aorta with mini aneurysm clip model. The expressions of iNOS and p38MAPK and the levels of biochemical parameters, including nitrite/nitrate, malondialdehyde (MDA), advanced oxidation products (AOPP), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were measured in control and experimental groups. IRI-induced rats treated with 10 mg/kg resveratrol protected spinal cord from ischemia injury as supported by improved biological parameters measured in spinal cord tissue homogenates. The resveratrol treatment significantly decreased the levels of plasma nitrite/nitrate, iNOS mRNA and protein expressions and phosphor...Continue Reading
Citations
Mar 19, 2020·Foods·Xiao MengHua-Bin Li
Dec 24, 2018·Microscopy Research and Technique·Xuehong LiuMarong Fang
Oct 2, 2019·Neural Regeneration Research·Bao-Ping XuXue-Jun Cui
Jun 25, 2020·Nutrients·Anna Winiarska-MieczanGrzegorz Wójcik
May 13, 2018·Bioscience Reports·Jinlou GaoLin Song
Jan 10, 2020·Oxidative Medicine and Cellular Longevity·Xing LiDingkun Lin
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christine TrabolsiMohamad Nasser
Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Xing LiDingkun Lin
Feb 2, 2021·Frontiers in Pharmacology·Jiamin WuXiang Zhong
Mar 23, 2021·Oxidative Medicine and Cellular Longevity·Anna Lucia FedulloIlaria Peluso
Apr 2, 2021·The Journal of Nutritional Biochemistry·Ibrahim JantanZeti-Azura Mohamed-Hussein
Apr 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sajad FakhriMasoumeh Jorjani
May 15, 2021·Frontiers in Genetics·Dan WangFengshou Chen
Jun 9, 2021·Neural Regeneration Research·Xiao-Min ZhangHong-Fu Wu
Aug 9, 2021·Neurochemical Research·Alireza SarkakiMaryam Adelipour
Aug 28, 2021·Biomedicines·Kristine StromsnesJuan Gambini
Dec 10, 2021·British Journal of Neurosurgery·Esra AslanMehmet Bilgehan Pektaş