Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

International Journal of Molecular Sciences
Youngjin HanYong Sang Song

Abstract

Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review.

References

Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·D FukumuraR K Jain
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lisa A RidnourDavid A Wink
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul R van GinkelArthur S Polans
Feb 23, 2008·Advances in Experimental Medicine and Biology·Weimin SunLurong Zhang
Mar 11, 2008·International Immunopharmacology·Yoolhee YangChul-Woo Kim
Aug 5, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hongzhong WuJianwen Liu
Feb 2, 2011·Investigative Ophthalmology & Visual Science·Jing HuaLois E H Smith
Feb 26, 2011·Annals of the Rheumatic Diseases·Sergei I Grivennikov, Michael Karin
Feb 23, 2011·Cancer Immunology, Immunotherapy : CII·Brenda L SotoPaul M Sondel
Jun 17, 2011·Journal of Cellular Physiology·Uzma ShamimAsfar S Azmi
Jan 6, 2012·International Journal of Oncology·Hisanori MikiAiro Tsubura
Oct 11, 2012·British Journal of Cancer·U HarjesA L Harris
Nov 3, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Md Ataur RahmanSung-Oh Huh
Sep 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catalina Lee-ChangArya Biragyn
Oct 31, 2013·Cancer Science·Yoshihiro KomoharaMotohiro Takeya
Dec 19, 2013·Critical Reviews in Food Science and Nutrition·Jocelyn M Sales, Anna V A Resurreccion
Feb 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeroen DekervelJos van Pelt
Jun 15, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Suthat ChottanapundMartin Van den Berg
Jul 1, 2014·Journal of Nutritional Science and Vitaminology·Takakazu MitaniRyoichi Yamaji
Oct 30, 2014·Nature Communications·Twan van den BeuckenBradly G Wouters
Jan 22, 2015·Cell Biochemistry and Biophysics·Liang ChenYunhe Xiong
Jan 27, 2015·Trends in Immunology·Jan MauerJens C Brüning
Jan 27, 2015·Pulmonary Circulation·Vadim ShlyonskyFrédérique Mies
Sep 25, 2015·Scientific Reports·Ang YuanPan-Chyr Yang
Jan 7, 2016·Asian-Australasian Journal of Animal Sciences·Jae-Hwan KimJin Wook Kim

❮ Previous
Next ❯

Citations

Feb 6, 2020·Biomolecules·Elizabeth VargheseDietrich Büsselberg
Apr 26, 2020·International Journal of Molecular Sciences·Massimiliano BerrettaNicola Maurea
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Anna E BarryHien Dang
Jul 30, 2020·International Journal of Molecular Sciences·Betina SchmidtEliane Fialho
Oct 10, 2020·Journal of Cancer Prevention·Rohini GomathinayagamDanny N Dhanasekaran
Nov 19, 2019·Pathology, Research and Practice·Pablo Igor Ribeiro FrancoMarina Pacheco Miguel
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kailong WangHaiyang Yu
Mar 11, 2020·Oncology Reviews·Ameneh JafariHakimeh Zali
Nov 15, 2019·Current Topics in Medicinal Chemistry·Sachin KumarHimangini Bansal
Mar 7, 2021·International Journal of Molecular Sciences·Veronica CocettaMonica Montopoli
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana S DiasIola F Duarte
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola MicaleAntonio Speciale
Aug 28, 2021·Biomolecules·Juwon LeeYong Sang Song
Sep 11, 2021·Molecular Nutrition & Food Research·Yen-Chun KohMin-Hsiung Pan
Dec 7, 2021·Archives of Gynecology and Obstetrics·Fangfang ChenSusanne Beyer
Jul 7, 2020·Anti-cancer Agents in Medicinal Chemistry·Palmiro PoltronieriGiovanna Giovinazzo

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
nuclear translocation
nuclear

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.