Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells

Regulatory Peptides
T IchikiKenji Sunagawa

Abstract

Resveratrol (3,5,4'-trihydroxystilbene), a polyphenol abundant in red wine, is known to extend the life span of diverse species. On the contrary, it was reported that angiotensin (Ang) II enhances senescence of vascular smooth muscle cells (VSMCs). We, therefore, examined whether resveratrol attenuates Ang II-induced senescence of VSMC. Senescence-associated β-galactosidase (SA β-gal) assay showed that Ang II induced senescence of VSMC. The Ang II-induced senescence was inhibited by losartan, an Ang II type 1 receptor (AT1R) antagonist but not by PD123319, Ang II type 2 receptor antagonist, indicating that AT1R is responsible for the induction of senescence. Resveratrol suppressed Ang II-induced senescence of VSMC in a dose-dependent manner. In addition, resveratrol suppressed Ang II-induced induction of p53 and its downstream target gene p21, both of which play an important role in the induction of senescence. Resveratrol suppressed senescence of VSMC possibly through inhibition of AT1R-dependent induction of p53/p21. Suppression of p53 induction may be involved in the longevity by resveratrol.

References

Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Aug 18, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hideharu FukaoJunichiro Yamamoto
May 30, 2006·Nature Reviews. Drug Discovery·Joseph A Baur, David A Sinclair
Jan 6, 2007·Circulation Research·Tohru Minamino, Issei Komuro
Feb 7, 2009·The Journal of Clinical Investigation·Ariela BenigniGiuseppe Remuzzi
Sep 5, 2009·Genes & Nutrition·Istvan LekliDipak K Das
Nov 16, 2010·Current Opinion in Nephrology and Hypertension·Johannes Stegbauer, Thomas M Coffman
Jul 13, 2011·Protein & Cell·Christopher L Brooks, Wei Gu

❮ Previous
Next ❯

Citations

Aug 26, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Philip Chiu-Tsun TangShun-Wan Chan
Dec 21, 2014·Journal of the American Heart Association·Farshad ForouzandehR Wayne Alexander
Apr 16, 2019·American Journal of Hypertension·Cameron G McCarthyBina Joe
Jun 29, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Anne Marie ThompsonEva M Rzucidlo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Molecular Nutrition & Food Research
Veronika Somoza
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
Tohru Minamino
© 2021 Meta ULC. All rights reserved