Resveratrol Chemosensitizes TNF-β-Induced Survival of 5-FU-Treated Colorectal Cancer Cells

Nutrients
Constanze BuhrmannMehdi Shakibaei

Abstract

Objective: Resveratrol, a safe and multitargeted natural agent, has been linked with inhibition of survival and invasion of tumor cells. Tumor Necrosis Factor-β (TNF-β) (Lymphotoxin α) is known as an inflammatory cytokine, however, the underlying mechanisms for its pro-carcinogenic effects and whether resveratrol can suppress these effects in the tumor microenvironment are poorly understood. Methods: We investigated whether resveratrol modulates the effects of 5-Fluorouracil (5-FU) and TNF-β on the malignant potential of human colorectal cancer (CRC) cells (HCT116) and their corresponding isogenic 5-FU-chemoresistant derived clones (HCT116R) in 3D-alginate tumor microenvironment. Results: CRC cells cultured in alginate were able to migrate from alginate and the numbers of migrated cells were significantly increased in the presence of TNF-β, similar to TNF-α, and dramatically decreased by resveratrol. We found that TNF-β promoted chemoresistance in CRC cells to 5-FU compared to control cultures and resveratrol chemosensitizes TNF-β-induced increased capacity for survival and invasion of HCT116 and HCT116R cells to 5-FU. Furthermore, TNF-β induced a more pronounced cancer stem cell-like (CSC) phenotype (CD133, CD44, ALDH1) and re...Continue Reading

References

Feb 15, 1994·International Journal of Cancer. Journal International Du Cancer·M T Dimanche-BoitrelF Martin
Aug 13, 1999·The American Journal of Physiology·D W PowellA B West
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Apr 27, 2001·Seminars in Cancer Biology·T D Tlsty
May 18, 2001·Nature·L A Liotta, E C Kohn
Mar 20, 2002·Cytokine & Growth Factor Reviews·Fran Balkwill
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Nov 29, 2002·The EMBO Journal·Lin-feng ChenWarner C Greene
Dec 18, 2002·Annals of the New York Academy of Sciences·Alok C Bharti, Bharat B Aggarwal
Jan 31, 2003·The Journal of Biological Chemistry·Jürgen R Müller, Ulrich Siebenlist
Jun 4, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ashok KumarBharat B Aggarwal
Sep 21, 2004·World Journal of Gastroenterology : WJG·Sheng-Li WuCheng-En Pan
Sep 24, 2004·Cancer Cell·Bharat B Aggarwal
Nov 18, 2004·Immunological Reviews·Kirsten SchneiderCarl F Ware
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tom Cupedo, Reina E Mebius
Mar 16, 2005·Cancer Cell·Frances BalkwillAlberto Mantovani
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
Sep 22, 2005·Nature Reviews. Immunology·Michael Karin, Florian R Greten
Mar 28, 2006·Biochemical Pharmacology·Bharat B Aggarwal, Shishir Shishodia
Apr 11, 2006·Molecular Cancer Research : MCR·Haitian LuChuanshu Huang
Aug 8, 2006·Biochemical Pharmacology·Bharat B AggarwalGautam Sethi
Sep 23, 2006·The New England Journal of Medicine·Craig T JordanMark Noble
May 4, 2007·Current Opinion in Pharmacology·Dinesh KhannaBharat B Aggarwal
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Piero DalerbaMichael F Clarke
Mar 29, 2008·Cell Stem Cell·Piero Dalerba, Michael F Clarke
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Gautam SethiBharat B Aggarwal
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce M Boman, Max S Wicha
Dec 10, 2008·Blood·John E Dick
Dec 17, 2008·Molecular Nutrition & Food Research·Mehdi ShakibaeiBharat B Aggarwal
Dec 17, 2008·International Journal of Cancer. Journal International Du Cancer·Peter ChuRobert J Peach
Feb 10, 2009·Current Pharmaceutical Biotechnology·Nitu Bansal, Debabrata Banerjee
Mar 6, 2009·Nature Reviews. Cancer·Kornelia Polyak, Robert A Weinberg
Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Stéphanie Gout, Jacques Huot
Apr 4, 2009·Nature Reviews. Cancer·Frances Balkwill
Jul 21, 2009·Immunobiology·Chiara PortaAntonio Sica
Aug 12, 2009·Current Opinion in Pharmacology·Bharat B Aggarwal, Prashasnika Gehlot
Sep 4, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lucia Ricci-VitianiRuggero De Maria
Dec 4, 2009·Translational Oncology·Yingjie YuAdhip Pn Majumdar
Mar 5, 2010·Clinical Pharmacology and Therapeutics·F Balkwill, A Mantovani
Mar 20, 2010·Cellular and Molecular Life Sciences : CMLS·Gaoliang OuyangChaoyong James Yang

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Citations

Nov 28, 2019·Autoimmunity·Farhana Muhammad YusoffNorhanani Mohd Redzwan
Nov 19, 2019·Current Cancer Drug Targets·Keywan MortezaeeAhmed E Musa
Aug 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan TauchenMichal Jurášek
Oct 20, 2018·Frontiers in Neuroscience·Luyao XuXuehong Liu
Apr 5, 2020·International Journal of Molecular Sciences·Constanze BuhrmannMehdi Shakibaei
May 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marlon OsorioCristina Castro
Jul 2, 2020·World Journal of Clinical Cases·Li-Yan WangJian-Bin Zhang
Feb 14, 2019·Journal of Biomedical Science·Tomasz KolendaKatarzyna Lamperska
Feb 23, 2019·International Journal of Molecular Sciences·Youngjin HanYong Sang Song
Oct 11, 2020·Materials·Kholoud Mohamed Ali SalimMohammad Tariqur Rahman
Oct 13, 2020·Pharmacology & Therapeutics·Laura MasuelliRoberto Bei
Jan 13, 2021·Cancers·Aranka BrockmuellerMehdi Shakibaei
Mar 7, 2021·International Journal of Molecular Sciences·Veronica CocettaMonica Montopoli
Apr 1, 2021·Cellular Oncology (Dordrecht)·Qingshan HuangWei Guo
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meng-Die YangShi-Bing Su
Aug 28, 2021·International Journal of Molecular Sciences·Kaya E WitteChristian Kaltschmidt

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Methods Mentioned

BETA
FCS
transmission electron microscopy
electron microcopy
acetylation

Software Mentioned

SPSS

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