Resveratrol combined with total flavones of hawthorn alleviate the endothelial cells injury after coronary bypass graft surgery

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Ying ZhuGuangjuan Zheng

Abstract

To explore the preventive and therapeutic effects of Resveratrol combined with total flavones of hawthorn, compatibility of traditional Chinese medicines, on the endothelial cells injury after artery bypass graft surgery. The animal model of coronary artery bypass grafting (CABG) was prepared by transplanting a segment of autologous jugular vein onto the transected common carotid artery in rabbits. After CABG surgery, the rabbits were administrated with saline (model group), aspirin (Aspirin group), resveratrol (Res group), total flavones of hawthorn (Haw group) and resveratrol combined with total flavones of hawthorn (Res+Haw group) once a day for eight weeks, respectively. Eight weeks later, the grafting arteries from all group were obtained for the pathomorphism observation, peripheral blood was collected to detect circulating endothelial cells (CECs) by flow cytometry. And the concentration of albumen and mRNA of ICAM-1 in the serum were measured by western blot and quantitative real-time polymerase chain reaction, respectively. Compared with the model group, the level of CECs density and the expressions of albumen and mRNA of ICAM-1 were significantly decreased in the aspirin,resveratrol,total flavones of hawthorn and resv...Continue Reading

Citations

Aug 21, 2019·Scandinavian Cardiovascular Journal : SCJ·M DiazM Azzawi
Jan 3, 2020·International Journal of Molecular Medicine·Wenjun RenHongrong Li
Dec 20, 2019·Experimental and Therapeutic Medicine·Bing LiZhao Hu
Mar 11, 2020·Frontiers in Pharmacology·Min WuYu Cao
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Negin ParsamaneshAmirhossein Sahebkar

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