Resveratrol Counteracts Insulin Resistance-Potential Role of the Circulation

Nutrients
Rachel H X Wong, Peter Howe

Abstract

Pre-clinical data and human trials indicate that resveratrol supplementation may help to counteract diabetes. Several mechanisms of action have been proposed to explain its metabolic benefits, including activation of sirtuins and estrogen receptors (ER) to promote glucose transporter type-4 (GLUT4) translocation and increase glucose uptake. Resveratrol can also enhance vasodilator function, yet the possibility that this action might help to alleviate insulin resistance in type-2 diabetes mellitus has received little attention. In this brief review we propose that, by restoring impaired endothelium-dependent vasodilatation in insulin resistant individuals resveratrol increases blood perfusion of skeletal muscle, thereby facilitating glucose delivery and utilization with resultant improvement of insulin sensitivity. Thus, circulatory improvements by vasoactive nutrients such as resveratrol may play a role in preventing or alleviating insulin resistance.

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Citations

Dec 24, 2018·Canadian Journal of Physiology and Pharmacology·Xavier Lieben LouisJeffrey T Wigle
Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Apr 3, 2019·International Journal of Molecular Sciences·Johannes M BreussPavel Uhrin
Sep 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vanessa Bullón-VelaJosé Alfredo Martínez
Feb 15, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dan-Dan HuangChuanlin Zhu
Sep 10, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jay Jay Thaung ZawRachel Hx Wong
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Negin ParsamaneshAmirhossein Sahebkar

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