Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells

American Journal of Reproductive Immunology : AJRI
Ayumi TaguchiYutaka Osuga

Abstract

Resistance to apoptosis, together with inflammatory and invasive activity, contributes to the pathogenesis of endometriosis; therefore, approaches that can safely enhance apoptosis in endometriotic tissue are highly sought after as a means of managing the disease. Although resveratrol (RVT) is known to induce apoptosis or increase sensitivity to apoptotic stimuli in various cancer cell types, its effect on human endometriosis has remained uncertain. This study aimed to investigate whether RVT induces or enhances apoptosis in human endometriotic stromal cells (ESCs). Endometriotic tissues were collected, during laparoscopies, from women affected by ovarian endometriosis. ESCs were prepared, cultured, and treated with RVT. Apoptosis was assessed by annexin V-PI staining. Survivin mRNA expression in ESCs was examined using RT-PCR. ESCs were pre-treated with or without RVT and then incubated with TNF-α-related-apoptosis-inducing ligand (TRAIL), which is a known pro-apoptotic molecule. RVT alone did not induce apoptosis in ESCs. RVT significantly reduced survivin mRNA expression (P < 0.05). Pre-treatment with RVT significantly enhanced TRAIL-induced apoptosis (8.13 ± 0.83% (control) versus 29.19 ± 7.39% (pre-treated with RVT), P < 0...Continue Reading

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Citations

Sep 1, 2017·Phytotherapy Research : PTR·Mehdi DadashpourMohammad Nouri
Feb 20, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mahshad KodarahmianAligholi Sobhani
Nov 23, 2019·Minerva medica·Bianca BiancoErik Montagna
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana-Maria DullCostin Vlad Anastasiu
Nov 8, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Weilin ZhengXuefang Liang
Oct 31, 2020·Human Reproduction Update·Gabriela F MeresmanMatthias W Laschke
Jul 3, 2021·Pharmaceuticals·Xia CaiShi-Wen Jiang
Aug 28, 2021·Nutrients·Ludovica BartiromoMassimo Candiani

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