Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Stephen E AlwayJunaith S Mohamed

Abstract

Older men (n = 12) and women (n = 18) 65-80 years of age completed 12 weeks of exercise and took either a placebo or resveratrol (RSV) (500 mg/d) to test the hypothesis that RSV treatment combined with exercise would increase mitochondrial density, muscle fatigue resistance, and cardiovascular function more than exercise alone. Contrary to our hypothesis, aerobic and resistance exercise coupled with RSV treatment did not reduce cardiovascular risk further than exercise alone. However, exercise added to RSV treatment improved the indices of mitochondrial density, and muscle fatigue resistance more than placebo and exercise treatments. In addition, subjects that were treated with RSV had an increase in knee extensor muscle peak torque (8%), average peak torque (14%), and power (14%) after training, whereas exercise did not increase these parameters in the placebo-treated older subjects. Furthermore, exercise combined with RSV significantly improved mean fiber area and total myonuclei by 45.3% and 20%, respectively, in muscle fibers from the vastus lateralis of older subjects. Together, these data indicate a novel anabolic role of RSV in exercise-induced adaptations of older persons and this suggests that RSV combined with exercis...Continue Reading

References

Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·S E AlwayW J Gonyea
Mar 1, 1988·Journal of Applied Physiology·S E AlwayA J McComas
May 1, 1993·Pflügers Archiv : European journal of physiology·J D Rosenblatt, D J Parry
Feb 1, 1993·Journal of Applied Physiology·W J RomanW J Gonyea
Feb 1, 1993·Journal of Applied Physiology·S E Alway, L A Starkweather
May 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S E AlwayP M Robitaille
Dec 16, 1998·Acta Physiologica Scandinavica·A K FerketichS E Alway
Oct 16, 2001·American Journal of Physiology. Cell Physiology·P O Mitchell, G K Pavlath
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Gregory R AdamsKenneth M Baldwin
Sep 26, 2003·American Journal of Preventive Medicine·Edward M CastilloElizabeth Barrett-Connor
Oct 16, 2004·American Journal of Physiology. Cell Physiology·Parco M SiuStephen E Alway
Nov 1, 2005·Cellular Signalling·Steven T RussellMichael J Tisdale
Jun 28, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chris J McNeil, Charles L Rice
Nov 22, 2007·Aging Cell·Béatrice ChabiDavid A Hood
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Parco M Siu, Stephen E Alway
Aug 8, 2009·Journal of Applied Physiology·C SuettaP Aagaard
Sep 24, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Janna R JacksonStephen E Alway
Apr 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Janna R JacksonStephen E Alway
May 12, 2011·Age·Geoffrey A PowerAnthony A Vandervoort
Jun 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yanlei HaoStephen E Alway
Jul 1, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Iman MomkenStéphane Blanc
Aug 11, 2011·Development·John J McCarthyCharlotte A Peterson
Dec 29, 2011·Case Reports in Medicine·Salaheddin SharifStephen E Alway
Dec 12, 2012·American Journal of Physiology. Cell Physiology·Michael F O'LearyDavid A Hood
Feb 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nikolett HartZsolt Radak
Jul 24, 2013·The Journal of Physiology·Lasse GliemannYlva Hellsten
Dec 18, 2013·Journal of Translational Medicine·Anna MontesanoIleana Terruzzi
Jan 21, 2014·Current Topics in Developmental Biology·Natasha C Chang, Michael A Rudnicki
Aug 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Lasse GliemannYlva Hellsten
Sep 12, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Trisha D ScribbansBrendon J Gurd
Jan 22, 2015·Medicine and Science in Sports and Exercise·Robert T MankowskiChristiaan Leeuwenburgh
May 20, 2015·The Journal of Experimental Biology·Rogier L C PlasRichard T Jaspers
Dec 8, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kristine R PolleyKevin McCully

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Citations

Sep 28, 2018·Journal of Cachexia, Sarcopenia and Muscle·Sophia Z LiuKevin E Conley
Feb 7, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Behrang AminiLeon Lenchik
Feb 17, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Paolo SgròLuigi Di Luigi
Sep 7, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·L de Freitas LimaA P B Moreira
Dec 14, 2019·The Journal of Clinical Endocrinology and Metabolism·John J DubéJames P DeLany
Jun 4, 2020·The American Journal of Clinical Nutrition·Marlies de LigtPatrick Schrauwen
Jun 15, 2019·Journal of Cachexia, Sarcopenia and Muscle·Matthew J MyersStephen E Alway
Jun 25, 2019·The Journal of Nutrition, Health & Aging·J E Morley
Jul 4, 2019·Current Pharmaceutical Design·Rosario Pastor, Josep A Tur
Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiawei ZhengJundong Zhu
Aug 8, 2019·International Journal of Molecular Sciences·Simona DamianoMariarosaria Santillo
Jan 4, 2019·European Journal of Nutrition·Pedro L ValenzuelaAlejandro Lucia
Dec 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ester Sara Di FilippoStefania Fulle
Feb 13, 2021·International Journal of Molecular Sciences·Itziar EseberriMaria P Portillo
Jan 30, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sujuan LiuLi Fu
Mar 12, 2021·The Journal of Nutritional Biochemistry·Zhihao QuAiling Liu
Mar 16, 2021·Exercise and Sport Sciences Reviews·Ashley N OliveiraDavid A Hood
May 3, 2021·Journal of Inherited Metabolic Disease·Nicoline LøkkenJohn Vissing
Jul 3, 2021·International Journal of Molecular Sciences·Lara CoppiMaurizio Crestani
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ming-Kuei ShihChih-Yao Hou
Aug 27, 2021·Metabolites·Alessandra RenziniLuca Madaro
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