Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome

Frontiers in Cellular Neuroscience
Ying-Cong YuYing Xu

Abstract

Irritable bowel syndrome (IBS) is at high risk of co-morbid depression and anxiety, which reduces patients' quality of life and increases the burden of health care costs. However, the pathophysiological mechanisms responsible for IBS still remain unknown. This study investigated the effects of resveratrol on stress-related depression, anxiety, intestinal and visceral dysfunction in rat model of IBS. Rats received chronic acute combining stress (CACS) for 22 days exhibited depression/anxiety-like behavior, visceral hypersensitivity and altered intestinal motility, as measured by the forced swimming, marble bury, abdominal withdrawal reflex (AWR) and intestinal tract motility (ITM) tests. These abnormalities were accompanied by reduced 5-hydroxytryptamine (5-HT) level in the hippocampus and increased 5-HT expression in the gut (ileum and colon) after CACS. Chronic treatment of IBS rats with resveratrol dose-dependently normalized CACS-induced both central nervous and peripheral dysfunction, which were consistent with its differentially regulating 5-HT contents in the brain and intestine. Pretreatment with the 5-HT1A receptor antagonist NAN-190 hydrobromide (NAN-190) prevented such effects. While sub-threshold of 5-HT1A receptor a...Continue Reading

References

Aug 4, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·R MarksteinD Hoyer
Sep 14, 2004·Journal of Neurobiology·Fernando Cervero, Jennifer M A Laird
Feb 14, 2006·British Journal of Pharmacology·Antonio Ramón MartínCatalina Alarcón de la Lastra
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Louis F Reichardt
Dec 9, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Ning ZouJiaming Qian
Jan 20, 2009·Brain Research Reviews·Julie A ChristiansonNathalie Vergnolle
Apr 1, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ying XuWilliam O Ogle
Apr 22, 2011·Exercise and Sport Sciences Reviews·Benjamin N Greenwood, Monika Fleshner
Dec 14, 2011·Frontiers in Physiology·Sue GrenhamTimothy G Dinan
Apr 6, 2013·Biogerontology·D Pérez-CáceresM Pallàs
Nov 28, 2015·Nutritional Neuroscience·Seyed Mohammad NabaviSeyed Fazel Nabavi
Feb 4, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Cristiane Kibune NagasakoMaria Aparecida Mesquita
May 10, 2016·Nature Reviews. Disease Primers·Paul EnckRobin C Spiller
Jun 29, 2017·The New England Journal of Medicine·Alexander C FordNicholas J Talley

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Citations

Jul 25, 2019·Chinese Medicine·Zhengrong ZhangGuoqi Zhu
Dec 18, 2020·Frontiers in Aging Neuroscience·Ji Yeon ChungJuhyun Song
Dec 3, 2020·Frontiers in Psychiatry·Alison Accarie, Tim Vanuytsel
Nov 12, 2020·Drug Design, Development and Therapy·FangTing YuanHeSheng Luo
Nov 6, 2021·Critical Reviews in Food Science and Nutrition·Zhenyu WangZhiyong He
Nov 25, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Nehal G GamalMohamed T Khayyal

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Methods Mentioned

BETA
Protein Assay

Software Mentioned

SPSS
Quantity One

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