Resveratrol improves vasoprotective effects of captopril on aortic remodeling and fibrosis triggered by renovascular hypertension

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Henrique Melo NatalinCarolina Baraldi Araujo Restini

Abstract

Renin-angiotensin system triggers vascular remodeling and fibrosis during the renovascular hypertensive two-kidney, one-clip (2K1C) model by oxidative-stress-mediated mechanisms. Thus, we hypothesized that the chronic treatment with the polyphenolic antioxidant resveratrol would improve the vasoprotective effects promoted by the chronic treatment with the angiotensin-converting enzyme inhibitor (ACEi) captopril in 2K1C hypertensive rats. Our main objective was to evaluate the effects of the combined treatment with resveratrol and captopril on vascular remodeling and fibrosis in 2K1C rats. Male Wistar rats underwent to unilateral renal stenosis by 2K1C Goldblatt model. Six weeks after surgery, rat systolic blood pressure (SBP) was measured by indirect tail-cuff plethysmography. 2K1C rats were considered hypertensive when presenting SBP higher than 160 mmHg and underwent resveratrol (20 mg/kg), captopril (6 or 12 mg/kg), or resveratrol (20 mg/kg) combined with captopril (6 or 12 mg/kg) treatment for 3 weeks. Nine weeks after surgery, rat SBP was measured, and rat thoracic aorta was isolated for histological assays with hematoxylin/eosin or Picrosirius Red to evaluate aortic remodeling and fibrosis, respectively. Oral treatment of...Continue Reading

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Citations

Dec 7, 2017·BioFactors·Yi-Rong LiChi-Chien Lin
Feb 27, 2020·International Journal of Hypertension·Yuejia DingJunping Zhang
Sep 1, 2017·Annals of the New York Academy of Sciences·Yu-Tang ChinLeroy F Liu
Feb 7, 2021·BioFactors·Seyede Atefe HosseiniAmirhossein Sahebkar

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