Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice

Surgery
Yun ChenWei-Jao Chen

Abstract

The prognosis of neuroblastoma patients remains unsatisfactory. Therefore, developing an effective treatment strategy is important. Resveratrol, a natural polyphenol, possesses chemopreventive and antitumor effects. We investigated the effects of resveratrol on the proliferation, apoptosis, and cell cycle alteration of neuroblastoma cells and determined its effects on neuroblastoma tumors in mice. Cytotoxic effects, cellular apoptosis, and alterations in the cell cycle were determined in neuro-2a neuroblastoma cells exposed for varying lengths of time to a series of resveratrol concentrations. Expression of associated cell cycle regulatory proteins, cyclin E and p21, was detected by Western blot analysis, and the antitumor effects of resveratrol were investigated by treating subcutaneous neuroblastoma tumors with intraperitoneal injections of 40 mg/kg resveratrol daily for 28 days. Resveratrol exerted cytotoxic effects on neuroblastoma cells. After resveratrol treatment, the apoptosis rate of the neuroblastoma cells significantly increased, a significant accumulation of cells occurred at the S phase of the cell cycle, p21 was downregulated, and cyclin E was upregulated. In addition, resveratrol treatment suppressed the growth r...Continue Reading

References

Jan 1, 1981·Journal of Neurology·M WeizsaeckerM Barker
Dec 6, 1996·Science·C J Sherr
Feb 7, 1997·Cell·M D JacobsonM C Raff
Feb 19, 1998·FEBS Letters·M FontecaveO Guittet
Apr 29, 1998·International Journal of Oncology·O P MgbonyebiI H Russo
Apr 17, 1998·Journal of Natural Products·N J SunR M Snapka
Aug 28, 1998·Science·N A Thornberry, Y Lazebnik
Sep 15, 1998·Biochemical and Biophysical Research Communications·F D RagioneV Zappia
Jun 8, 1999·Journal of Pediatric Surgery·A M DavidoffE F Vanin
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
Sep 22, 1999·European Journal of Biochemistry·M MacCarroneA F Agrò
Jan 16, 2002·Current Opinion in Genetics & Development·John A Hickman
Jul 11, 2002·British Journal of Cancer·A Carnero
Dec 25, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Wendy C Weinberg, Mitchell F Denning

❮ Previous
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Citations

Feb 23, 2011·Cancer Immunology, Immunotherapy : CII·Brenda L SotoPaul M Sondel
Sep 16, 2010·Calcified Tissue International·Katarzyna KupisiewiczJean-Marie Delaisse
Aug 29, 2007·Acta Pharmacologica Sinica·Lynne M HowellsMargaret M Manson
May 30, 2013·Cancer Cell International·Abdel-Moneim M OsmanOsman H Osman
Apr 22, 2015·Seminars in Cancer Biology·Mark A FeitelsonSomaira Nowsheen
Jul 26, 2011·The Journal of Nutritional Biochemistry·George NotasElias Castanas
Dec 23, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D CanistroM Paolini
Oct 2, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·F H LoK N Leung
Apr 15, 2005·Molecular Nutrition & Food Research·Sandra UlrichJürgen M Stein
Apr 1, 2009·International Journal of Cancer. Journal International Du Cancer·Didier ColinDominique Delmas
Apr 26, 2008·Molecular Nutrition & Food Research·Sonia Ramos
Jun 22, 2010·Journal of Cellular Biochemistry·Grégory GatouillatClaudie Madoulet
Jul 31, 2010·Journal of Surgical Oncology·Tessa M van GinhovenRon W F de Bruin
Jul 30, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Tao LiSan-Yuan Hu
Nov 13, 2009·International Journal of Cancer. Journal International Du Cancer·Kuzhuvelil B HarikumarBharat B Aggarwal
Aug 10, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Margaret M Manson
May 26, 2005·Mutation Research·H StopperK Kobras
Mar 11, 2008·International Immunopharmacology·Yoolhee YangChul-Woo Kim
Dec 27, 2005·Journal of Vascular Surgery·Bertrand PoussierBauer E Sumpio
Mar 6, 2012·Bioorganic & Medicinal Chemistry·Abdelrahman S MayhoubMark Cushman
Nov 26, 2011·Bioorganic & Medicinal Chemistry·Abdelrahman S MayhoubMark Cushman
Jul 30, 2014·The International Journal of Biochemistry & Cell Biology·Kumari AlkaGary T M Henehan
Sep 15, 2012·Nutrition Research and Practice·Hyun Sook LeeWoo Kyoung Kim
Apr 12, 2016·International Journal of Cancer. Journal International Du Cancer·Amanda I PhippsUNKNOWN Alliance for Clinical Trials in Oncology
Jul 1, 2016·Archives of Toxicology·Cláudia M DeusPaulo J Oliveira
Nov 24, 2016·Annals of the New York Academy of Sciences·Mohammad Amin Kamaleddin
Dec 2, 2017·International Journal of Molecular Sciences·Jeong-Hyeon KoKwang Seok Ahn
Dec 17, 2009·Anti-cancer Drugs·Nicoletta GaglianoIsabella Dalle-Donne
May 30, 2006·Nature Reviews. Drug Discovery·Joseph A Baur, David A Sinclair
Sep 14, 2020·Reviews in the Neurosciences·Kamil LeisPrzemysław Gałązka
Jun 21, 2019·Oxidative Medicine and Cellular Longevity·Saranya NavaneethaKrishnanKi-Young Lee
Oct 13, 2006·Journal of Neuro-oncology·Wei ZhangXiang Zhang

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