Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

International Journal of Obesity : Journal of the International Association for the Study of Obesity
S WangM Du

Abstract

Development of brown-like/beige adipocytes in white adipose tissue (WAT) helps to reduce obesity. Thus we investigated the effects of resveratrol, a dietary polyphenol capable of preventing obesity and related complications in humans and animal models, on brown-like adipocyte formation in inguinal WAT (iWAT). CD1 female mice (5-month old) were fed a high-fat diet with/without 0.1% resveratrol. In addition, primary stromal vascular cells separated from iWAT were subjected to resveratrol treatment. Markers of brown-like (beige) adipogenesis were measured and the involvement of AMP-activated protein kinase (AMPK) α1 was assessed using conditional knockout. Resveratrol significantly increased mRNA and/or protein expression of brown adipocyte markers, including uncoupling protein 1 (UCP1), PR domain-containing 16, cell death-inducing DFFA-like effector A, elongation of very long-chain fatty acids protein 3, peroxisome proliferator-activated receptor-γ coactivator 1α, cytochrome c and pyruvate dehydrogenase, in differentiated iWAT stromal vascular cells (SVCs), suggesting that resveratrol induced brown-like adipocyte formation in vitro. Concomitantly, resveratrol markedly enhanced AMPKα1 phosphorylation and differentiated SVC oxygen ...Continue Reading

References

Jan 12, 1996·The Journal of Biological Chemistry·D StapletonB E Kemp
Nov 8, 1996·The Journal of Biological Chemistry·B J MichellB E Kemp
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·G ZhaoT H Hintze
Mar 23, 2004·Biochemical and Biophysical Research Communications·Aina S LihnBjørn Richelsen
May 10, 2005·The Journal of Biological Chemistry·Marie DavalFabienne Foufelle
May 20, 2006·The Journal of Physiology·Marie DavalPascal Ferré
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Dec 15, 2006·Nature·Luc F Van GaalChristophe E De Block
Apr 11, 2008·Nature Reviews. Molecular Cell Biology·Adilson GuilhermeMichael P Czech
Aug 9, 2008·Phytotherapy Research : PTR·Srujana RayalamClifton A Baile
Aug 23, 2008·Nature·Patrick SealeBruce M Spiegelman
Nov 11, 2008·Archives of Medical Research·Maria Eugenia Frigolet Vázquez-VelaArmando R Tovar
Apr 10, 2009·The New England Journal of Medicine·Kirsi A VirtanenPirjo Nuutila
Sep 22, 2009·Analytical Biochemistry·Caroline DiepartBernard Gallez
Jan 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isabelle MaderSimone Fulda
Mar 23, 2010·European Journal of Pharmacology·Katarzyna Szkudelska, Tomasz Szkudelski
May 14, 2010·The American Journal of Clinical Nutrition·Pamela Fischer-PosovszkyMartin Wabitsch
Jan 6, 2011·Exercise and Sport Sciences Reviews·Mandeep Pinky Gaidhu, Rolando Bacis Ceddia
Jan 26, 2011·Annals of the New York Academy of Sciences·Clifton A BaileMary Anne Della-Fera
May 6, 2011·The Journal of Nutritional Biochemistry·Arrate LasaMaría del Puy Portillo
Sep 15, 2012·Nutrition Research and Practice·Xian-Hua ZhangJung-Sook Seo
Nov 14, 2012·Biochimica Et Biophysica Acta·Guillaume E BerangerEz-Zoubir Amri
Dec 19, 2012·Biochimica Et Biophysica Acta·M Luisa BonetAndreu Palou
Jan 10, 2013·Clinical Science·Silvia BijlandIan P Salt
Jan 15, 2013·Journal of Physiology and Biochemistry·Saioa Gomez-ZoritaChristian Carpéné
Feb 27, 2013·Diabetes & Metabolism Journal·Masayuki Saito
Mar 26, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria C Mitterberger, Werner Zwerschke
Apr 16, 2013·Cell Metabolism·Francesc Villarroya, Antonio Vidal-Puig
Apr 30, 2013·Experimental Gerontology·Yan Y LamEric Ravussin
May 15, 2013·Archives of Medical Science : AMS·Marisa CoelhoRuben Fernandes
Jun 1, 2013·Archives of Physiology and Biochemistry·Alessandro Peschechera, Juergen Eckel
Jun 26, 2013·Food Chemistry·Goiuri AlberdiMaría P Portillo
Jul 19, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Songbo WangQingyan Jiang
Aug 21, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E KoningsE E Blaak
Oct 9, 2013·Nature Medicine·Matthew Harms, Patrick Seale

❮ Previous
Next ❯

Citations

Jul 24, 2015·Molecular Nutrition & Food Research·Jon MerlinDana S Hutchinson
Sep 9, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L BrownS K Panchal
Jul 8, 2016·Adipocyte·Claude ForestPhilippe Noirez
Oct 5, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Marta GiraltFrancesc Villarroya
Nov 4, 2016·Nature Reviews. Endocrinology·Jan MartelJohn D Young
Oct 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yen-Chen TungMin-Hsiung Pan
Mar 25, 2017·Acta Biochimica Et Biophysica Sinica·Qingqing LiZhichun Yang
Jan 27, 2017·The Journal of Veterinary Medical Science·Jun A MinaguchiKazushige Takehana
Jan 21, 2017·American Journal of Respiratory Cell and Molecular Biology·David GozalAbdelnaby Khalyfa
Jan 31, 2017·The Journal of Nutritional Biochemistry·Sang Gil LeeHye Won Kang
Feb 12, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T MontanariM Colitti
Mar 30, 2017·European Journal of Pharmacology·Andrea D van DamVanessa van Harmelen
Jan 7, 2017·Biochimie·M Luisa BonetAndreu Palou
Jun 26, 2017·Trends in Endocrinology and Metabolism : TEM·Emily A DayGregory R Steinberg
Dec 12, 2017·Journal of Medicinal Food·Eric D TagueJay Whelan
Oct 25, 2017·BioFactors·Khan Mohammad ImranYong-Sik Kim
Apr 18, 2018·Journal of Gastroenterology and Hepatology·Lili NimriBetty Schwartz
Jun 8, 2018·The Journal of Endocrinology·Clara LefrancAurelie Nguyen Dinh Cat
Feb 6, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Pan WangFang Chen
Sep 25, 2017·Endocrine Reviews·Abdikarim Abdullahi, Marc G Jeschke
Jul 5, 2017·Hormone Molecular Biology and Clinical Investigation·Baskaran Thyagarajan, Michelle T Foster
Jul 15, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrea ArmaniMassimiliano Caprio
Jan 10, 2020·Food & Function·Tamara Y Forbes-HernándezMaurizio Battino
Feb 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zilun LiSifan Chen
Jan 4, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoxue YuanWanzhu Jin

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
Infrared Imaging
SGBS

Software Mentioned

Sigmaplot
Pro Plus
Image

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.