Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Yih HoPaul J Davis

Abstract

Leiomyomas (myomas) are the most common benign smooth muscle cell tumor of the myometrium. Resveratrol, a stilbene, has been used as an anti-inflammatory and antitumor agent. In the current study, we investigated the inhibitory effect of resveratrol on the proliferation of primary human myoma cell cultures. Resveratrol arrested cell proliferation via integrin αvβ3. It also inhibited integrin αvβ3 expression and protein accumulation. Concurrently, constitutive AKT phosphorylation in myoma cells was inhibited by resveratrol. Expressions of proapoptotic genes, such as cyclooxygenase (COX)-2, p21 and CDKN2, were induced by resveratrol in myoma cells. On the other hand, expressions of proliferative (anti-apoptotic) genes were either inhibited, as in BCL2, or unchanged, as in cyclin D1 and proliferating cell nuclear antigen (PCNA). The accumulation of insulin-like growth factor (IGF)-1 receptor (IGF-1R) was inhibited by resveratrol in primary myoma cells. IGF-1-induced cell proliferation was inhibited by co-incubation with resveratrol. Therefore, growth modulation of myoma cells occurs via mechanisms dependent on cross-talk between integrin αvβ3 and IGF-1R. Our findings suggest that resveratrol can be considered an alternative therap...Continue Reading

Citations

May 20, 2020·Journal of Clinical Medicine·Michał CiebieraAyman Al-Hendy
Jun 26, 2020·Physiological Reviews·Paul J DavisHung-Yun Lin
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dominique Vervandier-Fasseur, Norbert Latruffe
Apr 11, 2020·Reproductive Medicine and Biology·Asako Ochiai, Keiji Kuroda
Jul 25, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yi-Ru ChenKuan Wang
Jan 29, 2021·International Journal of Environmental Research and Public Health·Andrea TinelliRadmila Sparić
Dec 3, 2020·Antioxidants·Cristina Rodríguez-Varela, Elena Labarta
Dec 23, 2020·Viruses·Francesca BenedettiDavide Zella
Apr 9, 2021·Journal of Biomedical Science·Yu-Chen S H YangKuan Wang
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aline YammineNorbert Latruffe
Aug 3, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sandro GerliBernard Fioretti
Aug 31, 2021·Journal of Agricultural and Food Chemistry·Yen-Chun KohMin-Hsiung Pan

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