Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-κB

The International Journal of Biochemistry & Cell Biology
Ming-Horng TsaiI-Ta Lee

Abstract

Human fibroblast-like synoviocytes (FLSs) play a role in joint synovial inflammation in rheumatoid arthritis (RA). Some evidence indicates that particulate matter (PM) in air pollution could contribute to the progression of RA. However, more research is needed to clarify this relationship. Up-regulation of cyclooxygenase (COX)-2 and its metabolite prostaglandin E2 (PGE2) are implicated in various inflammatory diseases. Resveratrol, a polyphenol found mainly in grapes and red wine, has antioxidant and anti-inflammatory activities. In the present study, we demonstrated that resveratrol reduced PM-induced COX-2/PGE2 expression in human FLSs, and attenuated PM-enhanced NADPH oxidase activity and ROS generation. In addition, PM induced Akt, ERK1/2, or p38 MAPK activation, which was inhibited by resveratrol. Finally, we demonstrated that PM enhanced NF-κB p65 phosphorylation and the NF-κB promoter activity, which were reduced by pretreatment with a ROS inhibitor or resveratrol. Thus, we concluded that resveratrol functions as a suppressor of PM-induced inflammatory signaling pathways by inhibiting COX-2/PGE2 expression.

References

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Citations

Dec 2, 2017·Nutrients·Ana Lígia de Brito OliveiraMarta Chagas Monteiro
Oct 23, 2018·Journal of Periodontal Research·Mônica Grazieli CorrêaSuzana Peres Pimentel
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siyun SungBonglee Kim
Aug 18, 2020·Journal of Clinical Biochemistry and Nutrition·Tomoya KitakazeHitoshi Ashida
Oct 20, 2018·Frontiers in Neuroscience·Luyao XuXuehong Liu
Apr 11, 2019·Current Pharmaceutical Design·Tanzir RafeMd Abu Taher Sagor
Feb 11, 2021·Journal of Cellular Physiology·Hongyun LiuQiliang Zhang
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming-Horng TsaiI-Ta Lee
Oct 25, 2021·International Immunopharmacology·Yi-Jin WuJian Zuo

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