Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Dominika MánikováMiroslav Chovanec

Abstract

Resveratrol is a natural (poly)phenol primarily found in plants protecting them against pathogens, as well as harmful effects of physical and chemical agents. In higher eukaryotic cells and organisms, this compound displays a remarkable range of biological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-aging, cardio- and neuro-protective properties. Here, biological activities of synthetic selenium-containing derivatives of resveratrol-benzo[b]selenophenes-have been studied in lower eukaryotes Saccharomyces cerevisiae. Their toxicity, as well as DNA damaging and reactive oxygen species (ROS) inducing potencies, manifested through their ability to act as redox active anti-microbial agents, have been examined. We show that some benzo[b]selenophenes can kill yeast cells and that the killing effects are not mediated by DNA damage types that can be detected as DNA double-strand breaks. These benzo[b]selenophenes could potentially be used as anti-fungal agents, although their concentrations relevant to application in humans need to be further evaluated. In addition, most of the studied benzo[b]selenophenes display redox-modulating/anti-oxidant activity (comparable or even higher than that of resveratrol or Tro...Continue Reading

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Aug 16, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dominika MánikováMiroslav Chovanec
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Mar 8, 2016·Yeast·Luis Alberto Madrigal-PerezMinerva Ramos-Gomez

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Citations

Mar 28, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yannick NeyClaus Jacob
Jul 31, 2018·Mini Reviews in Medicinal Chemistry·Yulu MaChunping Wan
Jan 29, 2019·Mini Reviews in Medicinal Chemistry·Qing-Shan LiBan-Feng Ruan
Dec 5, 2018·Aging Clinical and Experimental Research·Zhonglin CaiHongjun Li
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paola S HellwigEder J Lenardão
May 4, 2021·Frontiers in Neuroscience·Daniel J TorresMarla J Berry

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Methods Mentioned

BETA
Electrophoresis
flow cytometry
NMR

Software Mentioned

FCS Express

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