Resveratrol is equipotent to perindopril in attenuating post-infarct cardiac remodeling and contractile dysfunction in rats

The Journal of Nutritional Biochemistry
Pema RajThomas Netticadan

Abstract

Angiotensin-converting enzyme (ACE) inhibitors improve prognosis in patients with post-myocardial infarction (MI) related cardiac dysfunction. Resveratrol is a polyphenol that has been reported to be beneficial in hypertension, ischemic heart disease, and cardiotoxicity in preclinical studies. Accordingly, we investigated the comparative and combinatorial efficacy of resveratrol and perindopril (ACE inhibitor) treatment on MI-related cardiac remodeling and contractile dysfunction. Left anterior descending artery-ligated and sham-operated male Sprague-Dawley rats were gavaged with vehicle, resveratrol, perindopril, and combination of resveratrol+perindopril (2.5 mg/kg bodyweight/day) for 8 weeks (starting immediately after acute MI). Echocardiography was performed to assess cardiac structure and function at baseline and 8 weeks. At 8 weeks, vehicle-MI rats had a significantly lower left ventricular ejection fraction (LVEF) and increased LV dilatation compared to vehicle-sham rats. MI rats treated with resveratrol, perindopril and a combination of both had significantly improved LVEF and reduced LV dilatation. Vehicle-treated MI rats also had increased level of lipid peroxidation product- malondialdehyde (MDA), proinflammatory pr...Continue Reading

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Citations

Mar 28, 2017·Journal of Medicinal Food·Sanghyun ChoJin Han
Dec 24, 2018·Canadian Journal of Physiology and Pharmacology·Xavier Lieben LouisJeffrey T Wigle
Jun 2, 2018·Oxidative Medicine and Cellular Longevity·P Aguilar-AlonsoA R Navarro-Cruz
Jul 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xavier Lieben LouisJeffrey T Wigle
Dec 29, 2020·Cellular Signalling·Alexandra M GarvinTaben M Hale
Jul 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaoqing ZhangHua Zhou
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pema RajShelley Zieroth
Jan 4, 2022·Critical Reviews in Food Science and Nutrition·Amirhossein SheidaHamed Mirzaei

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