Resveratrol-mediated cleavage of amyloid β1-42 peptide: potential relevance to Alzheimer's disease.

Neurobiology of Aging
Sarmad Al-EdresiJeffrey Penny

Abstract

Aggregation of amyloid β1-42 (Aβ1-42) peptide within the brain is considered one of the main causes of the neuropathological changes associated with Alzheimer's disease. Resveratrol is a well-known antioxidant but has also been reported to bind to Aβ1-42 peptide, thereby reducing aggregation. However, little is known of the precise mechanism by which resveratrol reduces Aβ1-42 peptide aggregation. Using the thioflavin-T assay, the ability of resveratrol to reduce the extent of Aβ1-42 peptide aggregation was investigated. The findings of the present study demonstrate that interaction of resveratrol with Aβ1-42 peptide resulted in the cleavage of Aβ1-42 peptide into smaller fragments, as detected by matrix assisted laser desorption ionization-time of flight mass spectrometry. Atomic force microscopy analyses revealed Aβ1-42 peptide, under control conditions, aggregated into oligomers, protofibrils, and fibrils, whereas there was a distinct lack of these structures when Aβ1-42 peptide was incubated with resveratrol. Following 10 days incubation of Aβ1-42 peptide with resveratrol, particles with a mean z-height of 1.940 nm (range 0.675-3.275 nm) were observed, which are characteristic of shorter peptide species. In cell-based studi...Continue Reading

References

Feb 1, 1996·Journal of Protein Chemistry·W B StineG A Krafft
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·T Kowalewski, D M Holtzman
Dec 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Aneta T PetkovaRobert Tycko
Apr 21, 2004·The Journal of Biological Chemistry·Min ZhuAnthony L Fink
Nov 6, 2004·The Journal of Biological Chemistry·Michael R NicholsTerrone L Rosenberry
Nov 24, 2004·Chemistry & Biology·Aphrodite Kapurniotu
May 30, 2006·Nature Reviews. Drug Discovery·Joseph A Baur, David A Sinclair
Oct 17, 2007·Chembiochem : a European Journal of Chemical Biology·Manuela BartoliniVincenza Andrisano
Aug 25, 2009·Experimental Gerontology·Milan Fiala, Robert Veerhuis
Jan 12, 2010·Journal of Alzheimer's Disease : JAD·Jian-Ping GuoPatrick L McGeer
Jan 26, 2011·Annals of the New York Academy of Sciences·Thomas Walle
Apr 19, 2011·Mass Spectrometry Reviews·Giuseppe Grasso
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaomin LiDennis J Selkoe
Apr 25, 2012·Methods in Molecular Biology·Valeriy OstapchenkoIlia V Baskakov
Sep 18, 2012·Neurochemistry International·Jin-Fang GeJiang-Ning Zhou
Feb 27, 2013·Chembiochem : a European Journal of Chemical Biology·Francesco AttanasioEnrico Rizzarelli
Apr 23, 2013·Brain : a Journal of Neurology·Marie OrreElly M Hol
Dec 19, 2013·Critical Reviews in Food Science and Nutrition·Jocelyn M Sales, Anna V A Resurreccion
Nov 26, 2014·Biochemistry·Ziao FuSteven O Smith
Jul 7, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Catherine KoukoulitsaThomas Mavromoustakos
Jan 15, 2016·Scientific Reports·Praveen Nedumpully-GovindanFeng Ding
May 1, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nikita RudinskiyAdrien W Schmid
Apr 3, 2019·Nutrients·Huong T T PhanMun'delanji C Vestergaard

❮ Previous
Next ❯

Citations

Jul 3, 2020·International Journal of Molecular Sciences·Xingyi ChengMingyao Yang
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ryuuta FukutomiMamoru Isemura
Mar 4, 2021·International Journal of Molecular Sciences·Joo-Hee LeeSeung-Hoon Yang
Apr 22, 2021·Degenerative Neurological and Neuromuscular Disease·Nafaa AlzobaidiMaaz Naqvi
Sep 3, 2020·European Journal of Pharmacology·Estera RintzGrzegorz Węgrzyn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.