Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice

Oxidative Medicine and Cellular Longevity
Xiaole TangShiyong Li

Abstract

Various lines of evidence suggest that neonatal exposure to general anesthetics, especially repeatedly, results in neuropathological brain changes and long-term cognitive impairment. Although progress has been made in experimental models, the exact mechanism of GA-induced neurotoxicity in the developing brain remains to be clarified. Sirtuin 1 (SIRT1) plays an important role in synaptic plasticity and cognitive performance, and its abnormal reduction is associated with cognitive dysfunction in neurodegenerative diseases. However, the role of SIRT1 in GA-induced neurotoxicity is unclear to date. In this study, we found that the protein level of SIRT1 was inhibited in the hippocampi of developing mice exposed to sevoflurane. Furthermore, the SIRT1 inhibition in hippocampi was associated with brain-derived neurotrophic factor (BDNF) downregulation modulated by methyl-cytosine-phosphate-guanine-binding protein 2 (MeCP2) and cAMP response element-binding protein (CREB). Pretreatment of neonatal mice with resveratrol nearly reversed the reduction in hippocampal SIRT1 expression, which increased the expression of BDNF in developing mice exposed to sevoflurane. Moreover, changes in the levels of CREB and MeCP2, which were considered to...Continue Reading

References

Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
May 3, 2002·Molecular Psychiatry·R S Duman
Feb 4, 2003·The Journal of Physiology·Jean-Claude Béïque, Rodrigo Andrade
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ingrid Ehrlich, Roberto Malinow
Nov 5, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nobuyuki TakeiHiroyuki Nawa
Jun 2, 2006·Apoptosis : an International Journal on Programmed Cell Death·Lucy X LuVesna Jevtovic-Todorovic
Apr 12, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·William SlikkerCheng Wang
Oct 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Pedro BekinschteinJorge H Medina
Jan 22, 2008·Progress in Neurobiology·Kihoon Han, Eunjoon Kim
Mar 18, 2010·Anesthesiology·Ansgar M BrambrinkJohn W Olney
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaday MichánValter D Longo
Aug 18, 2010·Progress in Neurobiology·Ana Rita SantosCarlos B Duarte
Dec 27, 2011·Anesthesiology·Matthew L PearnBrian P Head
Jun 9, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Loredana Zocchi, Paolo Sassone-Corsi
Oct 31, 2012·Annals of Neurology·Ansgar M BrambrinkJohn W Olney
Jan 1, 2013·Anti-cancer Agents in Medicinal Chemistry·Yan Wu, Feng Liu
Apr 17, 2013·Neuropharmacology·Nina N Karpova
Apr 23, 2013·Neuropharmacology·Graciano LealCarlos B Duarte
May 1, 2013·Journal of Medicinal Chemistry·Jay H Kalin, Joel A Bergman
Sep 26, 2013·Expert Reviews in Molecular Medicine·Anne L WidlundOle Vang
Oct 26, 2013·Anesthesiology·Catherine E CreeleyAnsgar M Brambrink
Nov 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaoqin ZhangZhongcong Xie
Feb 11, 2014·Neuron·A Zara Herskovits, Leonard Guarente
May 30, 2014·Molecular Neurobiology·Jie ZhangZhongcong Xie
Jun 6, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A Veronica WitteAgnes Flöel
Sep 6, 2014·Journal of Neurosurgical Anesthesiology·Yun Kyoung RyuCyrus D Mintz
Apr 4, 2015·Chemical Reviews·Mitchell H KeylorCorey R J Stephenson
Apr 25, 2015·Stroke; a Journal of Cerebral Circulation·Srinivasan V NarayananMiguel A Perez-Pinzon
Jul 23, 2015·Annals of the New York Academy of Sciences·Anya AlayevMarina K Holz

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Citations

Jan 19, 2021·Life Sciences·Fatma H ShakerHala O El-Mesallamy
Jul 27, 2021·Frontiers in Aging Neuroscience·Cong-Mei WangHe-Fan He

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Methods Mentioned

BETA
PCR
immunoprecipitation
Co-IP
coimmunoprecipitation
acetylation

Software Mentioned

GraphPad Prism
IP
Co
Image
GraphPad
AniLab
Pro Plus
AVTAS

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