Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation

Journal of Agricultural and Food Chemistry
Jia-Ni LinTzong-Der Way

Abstract

Resveratrol functions as an agonist for estrogen receptor (ER)-mediated transcription. However, other researchers have reported that resveratrol decreases proliferation of breast cancer cells that are either ER-positive or ER-negative, which suggests that the interaction of resveratrol with the ER may not fully explain its inhibitory effect on proliferation. Similar to those effects associated with caloric restriction (CR), resveratrol has multiple beneficial activities, such as increased life span and delay in the onset of diseases associated with aging. One key enzyme thought to be activated during CR is the AMP-activated kinase (AMPK), a sensor of cellular energy levels. The suppression of nonessential energy expenditure by activated AMPK along with the CR mimetic and antiproliferative properties of resveratrol has led us to hypothesize that resveratrol activity might have an important role in the activation of AMPK. Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells. Once activated, AMPK inhibited 4E-BP1 signaling and mRNA translation via mammalian target of rapamycin (mTOR). Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to induc...Continue Reading

References

Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·B D GehmJ L Jameson
Mar 24, 1999·Trends in Biochemical Sciences·B E KempL A Witters
Apr 12, 2001·Genes & Development·A C GingrasN Sonenberg
Oct 24, 2001·Cell·H VaziriR A Weinberg
Nov 29, 2002·The EMBO Journal·Lin-feng ChenWarner C Greene
Dec 3, 2002·Science·Blanka RoginaStewart Frankel
Dec 10, 2002·Brain Research·Qun WangAlbert Y Sun
Feb 6, 2003·Genes & Development·Jana Koubova, Leonard Guarente
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reuben J ShawLewis C Cantley
Mar 19, 2004·Nature·Hans-Guido WendelScott W Lowe
Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Oct 20, 2004·Cardiovascular Drug Reviews·Silvia BradamanteAlessandro Villa
Oct 13, 2005·Journal of Neurochemistry·Thimmappa S Anekonda, P Hemachandra Reddy
Dec 22, 2005·PLoS Biology·Laura BordoneLeonard Guarente
Apr 22, 2006·The Biochemical Journal·Jiandi Zhang
May 30, 2006·Nature Reviews. Drug Discovery·Joseph A Baur, David A Sinclair
Aug 3, 2006·Nature Reviews. Drug Discovery·Sandrine FaivreEric Raymond
Aug 23, 2006·Molecular and Cellular Biology·Maofu FuRichard G Pestell
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Jan 9, 2007·Trends in Molecular Medicine·Danica Chen, Leonard Guarente
Apr 4, 2007·Annals of the New York Academy of Sciences·Jin-Taek HwangOck Jin Park
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Biplab Dasgupta, Jeffrey Milbrandt
Apr 26, 2007·Molecular Endocrinology·Hiroyasu YamamotoJohan Auwerx

❮ Previous
Next ❯

Citations

Dec 29, 2010·Breast Cancer Research and Treatment·Puspa R PandeyKounosuke Watabe
Sep 26, 2013·Expert Reviews in Molecular Medicine·Anne L WidlundOle Vang
Sep 1, 2012·The British Journal of Nutrition·Ramaroson AndriantsitohainaIsmail Laher
Aug 2, 2012·Journal of Agricultural and Food Chemistry·Chao-Ming HungTzong-Der Way
Jun 2, 2012·Nature Reviews. Drug Discovery·Joseph A BaurRafael de Cabo
Sep 21, 2010·The Journal of Biological Chemistry·Meilian LiuFeng Liu
Jan 10, 2012·Biological & Pharmaceutical Bulletin·Seog Hyeon YounEil Sung Chang
Jan 14, 2012·PloS One·Eugenia Villa-CuestaPhilip A Gruppuso
Dec 14, 2011·The Journal of Endocrinology·R L MooreD V Faller
Dec 15, 2010·Future Oncology·Hany A OmarChing-Shih Chen
Dec 13, 2012·Future Oncology·Hany A OmarJing-Ru Weng
Jul 18, 2012·Molecular and Cellular Endocrinology·Kristy A BrownEvan R Simpson
Dec 21, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Chenguang WangRichard G Pestell
Oct 23, 2010·Pharmacology & Therapeutics·Antonio Paolo BeltramiCarlo Alberto Beltrami
Jul 28, 2015·Biochimie·Bhupender KumarRameshwar N K Bamezai
Sep 20, 2011·Journal of Cellular Biochemistry·Eliza VakanaLeonidas C Platanias
Oct 30, 2013·Journal of Cellular Biochemistry·Chih-Chien ChouChing-Shih Chen
Nov 30, 2010·Biochimica Et Biophysica Acta·Pedro L Prieto-HontoriaMaría J Moreno-Aliaga
Aug 19, 2014·Journal of Hepatology·Zheng Yun ZhangSung Joo Kim
Jun 27, 2013·Biotechnology Advances·Manju Saraswathy, Shaoqin Gong
May 17, 2011·Free Radical Biology & Medicine·Yi HuQingsong Liu
Nov 23, 2011·Clinical Neurology and Neurosurgery·Chao WangJun-sheng Wang
Jul 1, 2016·Archives of Toxicology·Cláudia M DeusPaulo J Oliveira
Jul 2, 2016·Nutrition and Cancer·Saad A HussainAmit K Tiwari
Nov 12, 2016·Nutrients·Aline Renata PavanJean Leandro Dos Santos
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Li ZhuoGuangyan Cai
Dec 14, 2017·Veterinary and Comparative Oncology·A CarlsonB N M Zordoky
Mar 24, 2012·World Journal of Diabetes·Bodo C Melnik
Feb 28, 2018·Molecular and Cellular Biology·Benjamin R E HarrisDa-Qing Yang
Sep 25, 2017·Nutrition and Cancer·Álvaro San Hipólito-LuengoConcepción Peiró
Jul 13, 2011·Journal of Receptor and Signal Transduction Research·Peter Kovacic, Ratnasamy Somanathan
Mar 1, 2012·Neuromolecular Medicine·Zhiyou CaiBin Zhao
Jan 16, 2020·International Journal of Molecular Sciences·Teodora CosteaMaria-Magdalena Mocanu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.