Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells.

The Journal of Nutrition
Andreas J PapoutsisDonato F Romagnolo

Abstract

The BRCA-1 protein is a tumor suppressor involved in repair of DNA damage. Epigenetic mechanisms contribute to its reduced expression in sporadic breast tumors. Through diet, humans are exposed to a complex mixture of xenobiotics and natural ligands of the aromatic hydrocarbon receptor (AhR), which contributes to the etiology of various types of cancers. The AhR binds xenobiotics, endogenous ligands, and many natural dietary bioactive compounds, including the phytoalexin resveratrol (Res). In estrogen receptor- alpha (ER alpha )-positive and BRCA-1 wild-type MCF-7 breast cancer cells, we investigated the influence of AhR activation with the agonist 2,3,7,8 tetrachlorobenzo(p)dioxin (TCDD) on epigenetic regulation of the BRCA-1 gene and the preventative effects of Res. We report that activation and recruitment of the AhR to the BRCA-1 promoter hampers 17 beta -estradiol (E2)-dependent stimulation of BRCA-1 transcription and protein levels. These inhibitory effects are paralleled by reduced occupancy of ER alpha , acetylated histone (AcH)-4, and AcH3K9. Conversely, the treatment with TCDD increases the association of mono-methylated-H3K9, DNA-methyltransferase-1 (DNMT1), and methyl-binding domain protein-2 with the BRCA-1 promote...Continue Reading

References

Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·B D GehmJ L Jameson
Nov 5, 1999·Molecular Cell·M E MoynahanM Jasin
May 25, 2001·Chemosphere·B RevichY Sotskov
Mar 29, 2002·Environmental and Molecular Mutagenesis·Jose RussoIrma H Russo
Apr 17, 2002·Japanese Journal of Clinical Oncology·Kazuaki MiyamotoToshikazu Ushijima
Jan 24, 2003·Annual Review of Pharmacology and Toxicology·Michael S Denison, Scott R Nagy
Jul 3, 2003·British Journal of Cancer·P FustierD J Bernard-Gallon
Apr 28, 2004·The Journal of Biological Chemistry·Soma S Ray, Hollie I Swanson
May 20, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ludovic Le CorreDominique Bernard-Gallon
Jun 18, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Clara Y Y ChanLouise M Winn
Aug 17, 2004·World Journal of Gastroenterology : WJG·Ying-Xuan ChenDe-Kai Qiu
Jan 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melinda C MyzakRoderick H Dashwood
Jul 19, 2006·Breast Cancer Research : BCR·Valgerdur BirgisdottirJorunn E Eyfjord
Sep 16, 2006·Biological Chemistry·Jennifer J SchlezingerDavid H Sherr
Sep 16, 2006·Molecular Nutrition & Food Research·Stefanie Knerr, Dieter Schrenk
Oct 31, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Darci T Butcher, David I Rodenhiser
Dec 13, 2006·Reproductive Toxicology·Sarah JenkinsCoral A Lamartiniere
Feb 27, 2007·Cell·Peter A Jones, Stephen B Baylin
Feb 27, 2007·Cell·Tony Kouzarides
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·David J BoocockDean E Brenner
Oct 4, 2007·Journal of Exposure Science & Environmental Epidemiology·Kevin T ConnorJ Craig Rowlands
Dec 7, 2007·The Journal of Steroid Biochemistry and Molecular Biology·S Medjakovic, A Jungbauer
Aug 21, 2008·Nutrition Reviews·Sharon A RossBarbara K Dunn
Sep 23, 2008·The International Journal of Biochemistry & Cell Biology·George ReidRaphaël Métivier
Oct 7, 2008·The International Journal of Biochemistry & Cell Biology·Sònia Guil, Manel Esteller
Dec 23, 2008·Epigenetics : Official Journal of the DNA Methylation Society·Rong LuJing-Yuan Fang
Jun 11, 2009·Molecular Cancer Therapeutics·Leigh EllisRicky W Johnstone
Aug 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kaname KawajiriYoshiaki Fujii-Kuriyama
Nov 28, 2009·Breast Cancer Research and Treatment·Wei JinZhi-Ming Shao

❮ Previous
Next ❯

Citations

Apr 12, 2011·Cardiovascular Toxicology·Brittany PalbykinOrnella I Selmin
Oct 14, 2011·Chemical Research in Toxicology·Shabana I KhanAsok K Dasmahapatra
Aug 6, 2013·Nutrition and Cancer·Gordana SupicZvonko Magic
Jul 6, 2012·Photochemistry and Photobiology·Saveria PastoreLiudmila Korkina
Feb 23, 2012·Journal of Nutrigenetics and Nutrigenomics·Thomas Prates OngSharon Ann Ross
Oct 25, 2011·Epigenomics·Tabitha M Hardy, Trygve O Tollefsbol
Feb 18, 2014·Endocrine-related Cancer·Kevin C KnowerColin D Clyne
May 29, 2013·Biochimica Et Biophysica Acta·Shaolong FengXinming Wang
Jan 4, 2013·Nutrition Reviews·Manoj KumarBirbal Singh
Jun 5, 2013·Nutrition Reviews·Philip B BusbeePrakash S Nagarkatti
Dec 7, 2013·The AAPS Journal·Vijay S ThakurSanjay Gupta
Jan 18, 2016·Seminars in Cancer Biology·Dona SinhaAnupam Bishayee
Feb 14, 2016·BioMedicine·Ling-Chu Chang, Yung-Luen Yu
Mar 13, 2016·Seminars in Oncology·Daoud MeerzamanSharon Ross
Apr 3, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wim Vanden Berghe
Jan 25, 2011·Clinical Epigenetics·Syed M MeeranTrygve O Tollefsbol
Nov 6, 2015·Molecules and Cells·Jinhyun RyuSang Soo Kang
Nov 9, 2011·Journal of Cellular Biochemistry·Wei YuWei Wang
Jul 25, 2013·Molecular Nutrition & Food Research·Vincent B Owona AyissiHermann Schluesenner
Sep 11, 2014·Critical Reviews in Food Science and Nutrition·Attilio GiacosaMariangela Rondanelli
Jun 12, 2014·Trends in Molecular Medicine·Ophélie Meynet, Jean-Ehrland Ricci
May 5, 2016·Molecular Nutrition & Food Research·Donato F RomagnoloOrnella I Selmin
Feb 6, 2017·Molecular Carcinogenesis·Eduardo Izquierdo-TorresAngel Zarain-Herzberg
Jun 30, 2016·PloS One·Rubiceli Medina-AguilarCésar López-Camarillo
Nov 7, 2017·Nutrients·Guilherme Felipe Santos FernandesJean Leandro Dos Santos
Mar 1, 2018·Frontiers in Immunology·Ping XueYufeng Zhou
Oct 19, 2017·Archives of Pharmacal Research·Qudeer Ahmed AbdulJae Sue Choi
May 18, 2019·Clinical Epigenetics·Shizhao LiTrygve O Tollefsbol
May 17, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Mukesh Verma
Nov 22, 2012·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Minju KimMihi Yang
Dec 22, 2016·Chinese Journal of Integrative Medicine·Xue-Qing Hu, Shi-Bing Su
Mar 19, 2019·Frontiers in Genetics·Ángeles Carlos-ReyesCésar López-Camarillo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.