Resveratrol promotes recovery of immune function of immunosuppressive mice by activating JNK/NF-κB pathway in splenic lymphocytes

Canadian Journal of Physiology and Pharmacology
Xin LaiZhongqiong Yin

Abstract

Resveratrol, a natural compound found in over 70 plants, is known to possess immunoregulatory effects and anti-inflammatory activity. It has been shown that resveratrol has regulatory effects on different signaling pathways in different diseases. However, few reports have evaluated the effects of resveratrol on reinforcing immunity recovery via activating nuclear factor-κB (NF-κB) pathway and Jun N-terminal kinases (JNK) pathway. The present study aimed to assess immune-enhancing activity and underlying mechanism of resveratrol in immunosuppressive mice. Previously, we reported that resveratrol could promote mouse spleen lymphocyte functions to recover the immune system effectively. In the present study, we show that resveratrol could upregulate the expressions of NF-κB, IκB kinase, JNK, and c-jun in splenic lymphocytes of immunosuppressive mice. Taken together, our results indicate that resveratrol could promote recovery of immunologic function in immunosuppressive mice by activating JNK/NF-κB pathway.

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Citations

Nov 23, 2017·Clinical and Experimental Pharmacology & Physiology·Shengxian LiuZhaomin Li
Mar 18, 2020·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Hana GreifováNorbert Lukáč
Oct 20, 2018·Frontiers in Neuroscience·Luyao XuXuehong Liu
Nov 22, 2018·Frontiers in Pharmacology·Ly Quoc Trung, Dao T T An
Dec 24, 2018·Microscopy Research and Technique·Xuehong LiuMarong Fang
Apr 2, 2021·The Journal of Nutritional Biochemistry·Ibrahim JantanZeti-Azura Mohamed-Hussein
Dec 28, 2021·Critical Reviews in Food Science and Nutrition·A S M Ali RezaEduardo Sobarzo-Sánchez

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