Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats

Brain Research Bulletin
Dan WanXiufeng Ye

Abstract

Dysfunction of energy metabolism can be a significant and fundamental pathophysiological basis for strokes. In studies of both humans and rodents, resveratrol, a natural polyphenol, has been reported to provide protection from cerebral ischemic injury by regulating expression of silent mating type information regulation 2 homolog 1 (SIRT1). However, direct evidence demonstrating that resveratrol exerts neuroprotection from cerebral ischemia injury by decreasing energy consumption is still lacking. Therefore, the aim of this study was to elucidate the mechanisms and signaling pathways through which resveratrol regulates energy metabolism in the ischemic brain, and to identify potential targets of resveratrol. ATP levels in brain tissues were detected by high performance liquid chromatography. SIRT1 and the phosphorylation of adenosine-monophosphate-activated protein kinase (P-AMPK) expressiones were evaluated by western blot. Levels of phosphodiesterase (PDEs) and cAMP were quantitated by real-time PCR and ELISA, respectively. Results showed that resveratrol significantly reduced the harmful effects of cerebral ischemic injury in vivo. Moreover, levels of ATP, p-AMPK, SIRT1, and cAMP were increased by resveratrol and PDE inhibit...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jul 8, 2000·Neuropathology and Applied Neurobiology·B S AspeyM J Harrison
Feb 15, 2001·Journal of Biomedical Science·A Y Sun, G Y Sun
Feb 14, 2002·Free Radical Biology & Medicine·Albert Y SunGrace Y Sun
Oct 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Han-Ting ZhangJames M O'Donnell
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Jan 27, 2004·Journal of Leukocyte Biology·Stephen W BuckJeffrey S Smith
Jun 11, 2004·Annual Review of Biochemistry·Gil Blander, Leonard Guarente
Mar 8, 2005·The Journal of Biological Chemistry·Margie T BorraJohn M Denu
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Biplab Dasgupta, Jeffrey Milbrandt
Aug 23, 2007·Nature Reviews. Molecular Cell Biology·D Grahame Hardie
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Aug 8, 2008·CNS Neuroscience & Therapeutics·Héctor I Rocha-GonzálezVinicio Granados-Soto
Mar 23, 2010·Molecular Neurobiology·Albert Y SunGrace Y Sun
Jul 17, 2013·Annals of the New York Academy of Sciences·Rachel H X WongPeter R C Howe
Jul 26, 2013·Expert Opinion on Therapeutic Targets·Wito RichterMarco Conti
Jan 15, 2014·Expert Review of Neurotherapeutics·Yanying Miao, James K Liao
Jun 10, 2014·The International Journal of Biochemistry & Cell Biology·Shih-Che HsuYu-Juei Hsu
Jun 24, 2014·Rejuvenation Research·Isabel F TresguerresJesús A F Tresguerres
Sep 10, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ran WangLing Wang
Oct 10, 2014·The Journal of Endocrinology·Michael RouseJosephine M Egan
Oct 16, 2014·Biochimica Et Biophysica Acta·Sameer S Kulkarni, Carles Cantó
Oct 16, 2014·Biochimica Et Biophysica Acta·Giulio Maria PasinettiLauren Dubner
Apr 25, 2015·Stroke; a Journal of Cerebral Circulation·Srinivasan V NarayananMiguel A Perez-Pinzon

❮ Previous
Next ❯

Citations

May 6, 2016·Nutrients·Dominique Bonnefont-Rousselot
Oct 30, 2016·Biochimica Et Biophysica Acta. General Subjects·Cheng-Lin ZhangLi-Ling Wu
Feb 15, 2017·Nutritional Neuroscience·Narayana Pineda-RamírezPenélope Aguilera
Jan 11, 2018·Oxidative Medicine and Cellular Longevity·Yu-Chen ChengYu-Chiang Hung
Feb 3, 2018·Oxidative Medicine and Cellular Longevity·Jingdian ZhangYing Zhang
Oct 20, 2018·Biomolecules & Therapeutics·John M Pezzuto
May 20, 2017·Current Medicinal Chemistry·Luca LiberaleFederico Carbone
Jul 5, 2017·Canadian Journal of Physiology and Pharmacology·Mohamed BejaouiHassen Ben Abdennebi
Jan 6, 2019·Journal of Molecular Neuroscience : MN·Hongmei ZhangZuning Liao
Apr 3, 2019·International Journal of Molecular Sciences·Johannes M BreussPavel Uhrin
Jul 25, 2019·Current Pharmaceutical Design·Kazuo Yamagata
Nov 2, 2019·Molecular Neurobiology·Narayana Pineda-RamírezPenélope Aguilera
Aug 28, 2020·Frontiers in Pharmacology·Concetta IsideLucia Altucci
Dec 7, 2018·Frontiers in Neuroscience·Jun-Fang ZhangYun-Cheng Wu
May 15, 2019·Cells·Edoardo ParrellaMarina Pizzi
Oct 6, 2020·Oxidative Medicine and Cellular Longevity·Fangzhou Jiao, Zuojiong Gong
Oct 13, 2020·Frontiers in Neuroscience·Yang-Hee KimJae-Young Koh
Mar 7, 2021·Cells·Giulietta Di BenedettoKonstantinos Lefkimmiatis
May 8, 2020·Experimental Neurology·Iván Alquisiras-BurgosPenélope Aguilera
May 20, 2021·Oxidative Medicine and Cellular Longevity·Hui XuMingfu Wang
Aug 9, 2021·Neurochemical Research·Alireza SarkakiMaryam Adelipour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.