Resveratrol regulates p66Shc activation in HaCaT cells

Experimental Dermatology
Gabriella FabbrociniDonatella Tramontano

Abstract

Skin is exposed to both endogenous and environmental oxidant agents, leading to the harmful generation of reactive oxygen species. Particular interest has been pointed on plant antioxidants, such as resveratrol, because of their wide-ranging biological activity and clinical potential. Resveratrol exerts antioxidant, metabolism-regulating and pro-apoptotic/anti-cancer effects on a variety of experimental models and has been suggested to protect skin from ultraviolet-induced photodamaging and photoaging. In parallel, also the biological significance of p66Shc, a member of the Src Homologue and Collagene homologue family with redox activity, is getting further attention. Because of the striking intersection among the activities of resveratrol with those of p66Shc, we investigated whether resveratrol would activate p66Shc in human immortalised keratinocytes (HaCaT cells), a well known and largely used model for skin keratinocytes. HaCaT cells were treated with resveratrol (10-150 μm) for different times. The effect of resveratrol on the proliferation of HaCaT cells and the activation of ERK1/2, AKT, and p66Shc was investigated by cell counting, fluorescence-activated cell sorting, and western blot analysis of total or immunoprecipi...Continue Reading

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Citations

Nov 22, 2013·PloS One·Nicoletta VitaleDonatella Tramontano
Feb 26, 2011·American Journal of Clinical Dermatology·Gabriella FabbrociniFabio Ayala
Sep 1, 2015·Annals of the New York Academy of Sciences·Ole Vang
Mar 7, 2013·Journal of Receptor and Signal Transduction Research·Deeba KirmaniFirdous A Khanday
Sep 21, 2016·International Journal of Molecular Sciences·Andrea ConteDonatella Tramontano
Mar 19, 2016·British Journal of Pharmacology·Fabio Di LisaRainer Schulz

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