Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study

Journal of Medicinal Food
Bushra Hassan MaroufRunj Simko Ahmmad

Abstract

Resveratrol, a polyphenolic compound, is a powerful antioxidant with remarkable anti-inflammatory properties. Inflammation and pain plays an important role in the pathogenesis of knee osteoarthritis (OA) and could cause tissue damage and morbidity. The aim of this study was to evaluate the anti-inflammatory and pain reduction activities of orally administered resveratrol in patients with knee OA. We carried out a 90-day pilot study to evaluate the ability of orally administered resveratrol, as an adjuvant with meloxicam, to decrease knee joint pain and biomarkers of inflammation in comparison with a placebo. One hundred ten men and women (45-75 years old) diagnosed with mild to moderate knee OA were treated with 15 mg per day meloxicam and either 500 mg per day resveratrol or placebo for 90 days in a double-blind, randomized control trial. Pain severity was evaluated at the beginning and at the end of treatment using Visual Analogue Scale-100 scores. Fasting blood was collected to determine serum interleukins 1β and 6, tumor necrosis factor-α, C-reactive protein, and complement proteins C3 and C4. The resveratrol-treated group experienced a time-dependent significant decrease in pain severity (P < .001). Serum levels of the bio...Continue Reading

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Citations

Apr 19, 2019·Bioscience Reports·Zhenhan DengFangjie Zhang
Jun 27, 2020·Antioxidants & Redox Signaling·Nickolas AuclairEmile Levy
Nov 24, 2020·Experimental Gerontology·Francesco Dernie, Daniel Adeyoju
Jun 12, 2021·The American Journal of Pathology·Jacqueline T HechtKaren L Posey

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Graph Pad
Graph Pad Prism

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