Resveratrol Suppresses Prostate Cancer Epithelial Cell Scatter/Invasion by Targeting Inhibition of Hepatocyte Growth Factor (HGF) Secretion by Prostate Stromal Cells and Upregulation of E-cadherin by Prostate Cancer Epithelial Cells

International Journal of Molecular Sciences
Tze-Chen Hsieh, Joseph M Wu

Abstract

Cancer mortality is primarily attributed to metastasis and the resulting compromise of organs secondary to the initial tumor site. Metastasis is a multi-step process in which the tumor cells must first acquire a migratory phenotype and invade through the surrounding tissue for spread to distant organs in the body. The ability of malignant cells to migrate and breach surrounding tissue/matrix barriers is among the most daunting challenges to disease management for men in the United States diagnosed with prostate cancer (CaP), especially since, at diagnosis, a high proportion of patients already have occult or clinically-detectable metastasis. The interaction between hepatocyte growth factor (HGF) secreted by the stroma, with its receptor c-Met located in the epithelium, must occur for epithelial CaP cells to become migratory. We studied the effects of grape-derived phytochemical resveratrol on the transition of epithelial tumor cells from sedentary to a mobile, penetrant phenotype. A time lapse microscopy assay was used to monitor the acquisition of the migratory phenotype by resveratrol. The results show that resveratrol inhibits HGF-mediated interaction between the stroma and epithelium and suppresses epithelial CaP cell migra...Continue Reading

References

Jun 1, 1989·Journal of Cellular Physiology·M Stoker
Sep 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M JeffersG F Vande Woude
Jun 1, 1997·The Journal of Investigative Dermatology·N MatsuyoshiS Imamura
Aug 24, 1999·Cancer Metastasis Reviews·D R Rowley
Mar 16, 2000·International Journal of Experimental Pathology·K A StuartG G Skouteris
Dec 21, 2002·Differentiation; Research in Biological Diversity·Gerald R CunhaY Z Wang
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Gerald R CunhaWilliam A Ricke
Oct 7, 2003·Oncogene·Thomas Bogenrieder, Meenhard Herlyn
Nov 1, 2003·American Journal of Physiology. Cell Physiology·Anne L PollackKeith E Mostov
Aug 26, 2004·Advances in Cancer Research·Beatrice S Knudsen, Magnus Edlund
Jan 25, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Gerald R CunhaTakeshi Kurita
Jun 17, 2005·Cancer Research·Wai Kei KwokXianghong Wang
Oct 8, 2005·Cell Motility and the Cytoskeleton·C M WellsG E Jones
Oct 10, 2006·Clinical Genitourinary Cancer·Leland W K ChungHaiyen E Zhau
Dec 2, 2009·Seminars in Cell & Developmental Biology·Sajni JossonRuoxiang Wang
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Jung-Kang JinGary E Gallick
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Robert R Langley, Isaiah J Fidler
Oct 28, 2014·Translational Andrology and Urology·Campbell M Grant, Natasha Kyprianou
Dec 3, 2014·Biochemical and Biophysical Research Communications·Xin YaoHector Biliran
Feb 18, 2017·Molecular Cancer Research : MCR·Amber E de GrootSarah R Amend
Jun 10, 2017·Cytokine & Growth Factor Reviews·Antonella SistiguPaola Nisticò
Sep 20, 2018·Advances in Experimental Medicine and Biology·Valerie Odero-MarahJanae Sweeney
May 8, 2019·Developmental Cell·Wei Lu, Yibin Kang

❮ Previous
Next ❯

Citations

Feb 7, 2021·Nutrients·Michał OczkowskiJoanna Gromadzka-Ostrowska
Oct 24, 2020·ACS Combinatorial Science·Milad AshrafizadehPooyan Makvandi
Feb 5, 2021·Journal of Xenobiotics·Natalie SilkDianzheng Zhang
Aug 20, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaodong ChenYugong Feng

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
GTPases
Assay
ELISA
PCR
protein assay
electrophoresis

Software Mentioned

Adobe Photoshop

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.