Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting α-Glucosidase

Journal of Agricultural and Food Chemistry
Xiaohui ZhaoHuilan Yue

Abstract

The regulation of postprandial blood glucose (PBG) levels is an effective therapeutic method to treat diabetes and prevent diabetes-related complications. Resveratroloside is a monoglucosylated form of stilbene that is present in red wine, grapes, and several traditional medicinal plants. In our study, the effect of resveratroloside on reducing PBG was studied in vitro and in vivo. In comparison to the starch treatment alone, the oral administration of resveratroloside-starch complexes significantly inhibited the PBG increase in a dose-dependent pattern in normal and diabetic mice. The PBG level treated with resveratrol (30 mg/kg) was not lower than that of resveratroloside. Further analyses demonstrated that resveratroloside strongly and effectively inhibited α-glucosidase, with an 50% inhibitory concentration value of 22.9 ± 0.17 μM, and its inhibition was significantly stronger than those of acarbose and resveratrol (264 ± 3.27 and 108 ± 2.13 μM). Moreover, a competitive inhibition mechanism of resveratroloside on α-glucosidase was determined by enzyme kinetic assays and molecular docking experiments. The molecular docking of resveratroloside with α-glucosidase demostrated the competitive inhibitory effect of resveratrolosid...Continue Reading

References

Jun 1, 1997·Journal of Natural Products·M ManickamA B Ray
Feb 26, 2000·Journal of Agricultural and Food Chemistry·B C VastanoR T Rosen
Aug 18, 2005·The Journal of Pharmacy and Pharmacology·Isabel Rivero-CruzRachel Mata
Oct 11, 2005·Archives of Pharmacal Research·Sang Zin ChoiKang Ro Lee
Oct 14, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jian Mei LiChristopher H K Cheng
Sep 28, 2010·Journal of Medicinal Chemistry·Mar LarrosaJuan Carlos Espín
Oct 9, 2012·The Journal of Pharmacology and Experimental Therapeutics·Ryusuke HosodaYoshiyuki Horio
Apr 4, 2013·Cardiovascular & Hematological Agents in Medicinal Chemistry·Sergey E NaumenkoGenrikh A Tolstikov
Sep 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ali MovahedThomas Netticadan
Apr 18, 2014·Indian Journal of Endocrinology and Metabolism·Sanjay KalraA G Unnikrishnan
Sep 25, 2014·Diabetes Care·Angelo Avogaro, Gian Paolo Fadini
Dec 3, 2014·Biochimica Et Biophysica Acta·Tomasz Szkudelski, Katarzyna Szkudelska
Aug 8, 2015·Annals of the New York Academy of Sciences·Kei ShimodaHiroki Hamada
Sep 24, 2016·Archives of Pharmacal Research·Jung-Hwan Kang, Se-Young Choung
Feb 10, 2017·The Journal of Clinical Endocrinology and Metabolism·Thomas Nordstrøm KjærSteen Bønløkke Pedersen
Jun 2, 2017·The Journal of Nutritional Biochemistry·Albert J ZhangSuresh T Mathews
Sep 7, 2017·Journal of Agricultural and Food Chemistry·Bo-Wei ZhangYue-Sheng Dong

❮ Previous
Next ❯

Citations

Mar 29, 2019·Antioxidants·Christian CarpénéVíctor López
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Malose J MphahleleYee Siew Choong
Nov 6, 2021·Food & Function·Zenggen LiuQingyan Shu
Dec 30, 2021·Journal of Agricultural and Food Chemistry·Zhi-Wei HouGuan-Hu Bao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.