Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons

Cell Reports
Nina HoyerPeter Soba

Abstract

Dendrite morphogenesis is a highly regulated process that gives rise to stereotyped receptive fields, which are required for proper neuronal connectivity and function. Specific classes of neurons, including Drosophila class IV dendritic arborization (C4da) neurons, also feature complete space-filling growth of dendrites. In this system, we have identified the substrate-derived TGF-β ligand maverick (mav) as a developmental signal promoting space-filling growth through the neuronal Ret receptor. Both are necessary for radial spreading of C4da neuron dendrites, and Ret is required for neuronal uptake of Mav. Moreover, local changes in Mav levels result in directed dendritic growth toward regions with higher ligand availability. Our results suggest that Mav acts as a substrate-derived secreted signal promoting dendrite growth within not-yet-covered areas of the receptive field to ensure space-filling dendritic growth.

Citations

May 17, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasutetsu KanaokaYukako Hattori
Feb 2, 2021·Frontiers in Cellular Neuroscience·Tzu-Yang LinChi-Hon Lee
Jan 18, 2021·Current Opinion in Neurobiology·Artur Kania
Apr 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Grace Ji-Eun ShinWesley B Grueber
May 19, 2021·Developmental Biology·Delia RicoloSofia J Araújo
Jun 18, 2021·Frontiers in Cellular Neuroscience·Chang YinJay Z Parrish
Nov 23, 2021·Frontiers in Cellular Neuroscience·Brikha R ShresthaWesley B Grueber

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