RET rearrangements in post-Chernobyl papillary thyroid carcinomas with a short latency analysed by interphase FISH.

British Journal of Cancer
K UngerH Zitzelsberger

Abstract

Tissue samples from 13 post-Chernobyl childhood thyroid tumours that occurred within a short period of time (4-8 years) after the Chernobyl accident have been investigated by interphase FISH analysis for rearrangements of RET. In all, 77% of cases showed RET/PTC rearrangements and a distinct intratumoural genetic heterogeneity. The data were compared to findings on 32 post-Chernobyl PTCs that occurred after a longer period of time (9-12 years) after the accident. In none of the cases from either group were 100% of cells positive for RET rearrangement. In addition, the pattern of RET-positive cells was different in the two groups (short vs longer latency). A significant clustering of aberrant cells could be detected in the long-latency subgroup, whereas the aberrant cells were more homogeneously distributed among the short-latency tumours. The findings suggest that oligoclonal tumour development occurs in post-Chernobyl PTCs. This pattern of different clones within the tumour appears to become more discrete in cases with longer latencies, suggesting either outgrowth of individual clones or development of later subclones with time.

References

Sep 3, 1992·Nature·V S KazakovL N Astakhova
Sep 3, 1992·Nature·K BaverstockD Williams
Aug 6, 1998·Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology·O Ferrer-RocaM Estévez
Dec 15, 2000·Oncogene·S M Jhiang
May 20, 2004·British Journal of Cancer·E D WilliamsG A Thomas
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Kristian UngerGerry Thomas

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Citations

May 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Julia HessKristian Unger
Jul 3, 2013·Archives of Pathology & Laboratory Medicine·Andrew H FischerMojgan Amrikachi
Jan 27, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Daria Handkiewicz-JunakBarbara Jarzab
Nov 30, 2006·Journal of Surgical Oncology·Jennifer E Rosen, Michael D Stone
Jun 6, 2009·Virchows Archiv : an International Journal of Pathology·Tadao NakazawaRyohei Katoh
Aug 29, 2019·Frontiers in Endocrinology·Francesca GaluppiniCaterina Mian
Aug 31, 2018·Radiation Protection Dosimetry·Geraldine Thomas
Oct 19, 2010·Cancer Genetics and Cytogenetics·Paola Caria, Roberta Vanni
Dec 5, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Horst ZitzelsbergerKristian Unger
Dec 8, 2009·Molecular and Cellular Endocrinology·Horst ZitzelsbergerKristian Unger
Feb 15, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·H Zitzelsberger, K Unger

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Methods Mentioned

BETA
fluorescence microscopy

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